Summaries & Associations of Study Results
TR-319 1,4-Dichlorobenzene (p-Dichlorobenzene)
Target Organs and Levels of Evidence
NTP Technical Report Number 319
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| 1,4-DICHLOROBENZENE (P-DICHLOROBENZENE) 106-46-7 |
03/26/86 | INSECTICIDAL FUMIGANT, GERMICIDE, INTR IN MANUF. OF DICHLOROANILINE, DYES, IN PHARMACEUTICALS, DEODORANT FOR GARBAGE & RESTROOMS (HSDB 1990) | Gavage MR: 0,150,300 MG/KG, FR: 0,300,600 MG/KG, M: 0,300,600 MG/KG/50 PER GROUP | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | KIDNEY TUBULAR CELL: ADENOCARCINOMA 1/50 3/50 7/50 | |||
| NON-NEOPLASTIC LESIONS: | KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; HYPERPLASIA, EPITHELIAL, PELVIS; MINERALIZATION, TUBULE; HYPERPLASIA, EPITHELIAL, TUBULE | |||
| FR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: NEPHROPATHY | |||
| MM: CLEAR EVIDENCE | LIVER: ADENOMA 5/50 13/49 16/50; CARCINOMA 14/50 11/49 32/50 | |||
| MAY HAVE BEEN RELATED: | ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 0/47 2/48 4/49 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: CYTOMEGALY; KARYOMEGALY; DEGENERATION; NECROSIS | |||
| THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL | ||||
| ADRENAL GLAND: HYPERPLASIA, MEDULLA; HYPERPLASIA, CAPSULE | ||||
| FM: CLEAR EVIDENCE | LIVER: ADENOMA 10/50 6/48 21/50; CARCINOMA 5/50 5/48 19/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: CYTOMEGALY; KARYOMEGALY; DEGENERATION; NECROSIS | |||
Web page last updated on February 10, 2006
