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Office of the National Toxicology Program

The National Toxicology Program (NTP) ( is an interagency program established in 1978 by the Secretary of Health, Education and Welfare, which today is known as the U.S. Department of Health and Human Services. The program was created as a cooperative effort to coordinate toxicology testing programs within the federal government, strengthen the science base in toxicology, develop and validate improved testing methods, and provide information about potentially toxic chemicals to health, regulatory, and research agencies, scientific and medical communities, and the public. NTP is headquartered at the NIEHS. The NIEHS Director ( also serves as NTP Director. NTP´s advisory groups ( provide regular external input to the program on its activities and policies, ensuring their high quality and relevance. The NTP Web site catalogues programmatic activities including its cancer and other toxicology studies, special centers, external advisory groups, and events.

John R. Bucher, Ph.D.
John R. Bucher, Ph.D.
Associate Director, NTP

Tel (919) 541-4532
Fax (919) 541-4255

P.O. Box 12233
Mail Drop EC-34
Research Triangle Park, North Carolina 27709
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The NTP Associate Director manages the day-to-day operations, planning and implementing activities and policies necessary to carry out the NTP’s goals. Bucher works with the NTP Director in administrative management of the NTP, represents the director in his absence or as designated, and with assistance from the Deputy Program Directors serves as liaison between NTP and other federal agencies, the scientific and medical communities, and the public.

Logo of the National Toxicology Program (NTP)Bucher joined the NTP as a toxicologist in 1983 and since then has played a key role in shaping the program’s research and policies. Most recently, he played a major role in developing the NTP Vision and Roadmap for the 21st Century (, a plan for toxicology research to advance as a predictive science, building on the knowledge gained from traditional single-agent studies primarily in rodents. He previously directed the evaluation of several experimental models using genetically modified mice as alternatives to the standard 2-year rodent cancer assays, and maintains an interest the developing improved toxicology methods. He organized one of the first conferences to explore the field of nanotoxicology and has advised congressional staff about this critically important emerging area of science.

Bucher is an internationally recognized expert in the design and interpretation of cancer bioassays, and has authored a number of important publications examining critical issues in dose selection for toxicology and cancer studies. He holds a doctorate in pharmacology from the University of Iowa, a Masters of Science in biochemistry from the University of North Carolina at Chapel Hill, and a Bachelor of Arts in biology from Knox College in Galesburg, Illinois.

Scientific and Support Staff

Nigel Walker, Ph.D.
Deputy Program Director for Science
Tel (919) 541-4893
Fax (301) 451-5596

Mary S. Wolfe, Ph.D.
Deputy Program Director for Policy
Tel (919) 541-7539
Fax (919) 541-0295

Bonnie Allen
Administrative Specialist
Tel (919) 541-3449
Fax (919) 541-4255

Sharon Nichols
Intramural Program Specialist
Tel (919) 541-7992
Fax (919) 541-3647

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Last Reviewed: February 08, 2008