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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR324 IGR325 IGR328 IGR326 IGR329 IGR322 IGR331 IGR323 IGR327 IGR330 SMu0365 SMu0366 SMu0367 pfl, - SMu0363 SMu0370 SMu0368 dinP,umuC,mucB, - SMu0364 SMu0371 SMu0369 SMu0365 SMu0366 SMu0367 pfl, - SMu0363 SMu0370 SMu0368 dinP,umuC,mucB, - SMu0364 SMu0371 SMu0369 SMu0366 SMu0367 pfl, - SMu0363 SMu0365 SMu0370 SMu0368 dinP,umuC,mucB, - SMu0364 SMu0371 SMu0369


LANL Gene ID: SMu0367

GenBank Locus Tag: SMU.406c

DNA Molecule Name:
1  

GenBank ID:
24378899

Gene Name:


Definition:
haloacid dehalogenase-like hydrolase

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
381367

Gene Stop:
380555

Gene Length:
813

Molecular Weight*:
31155

pI*:
10.10

Net Charge*:
9.65

EC:
 

Functional Class:
Unassigned  

Gene Ontology:
Biological process
  GO:0008152    metabolic process

Molecular function
  GO:0003824    catalytic activity
  GO:0016787    hydrolase activity


Pathway: pathway table

Comment:


View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-270 are 61% similar to gi15675586 from S.pyogenesand 56% similar to gi15902307 from S.pneumoniae.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0362 (1e-104).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24378899|ref|NP_720854.1|  hypothetical protein SMU.406c ...   509   e-143
 gi|77414455|ref|ZP_00790606.1|  hydrolase, haloacid dehaloge...   364   3e-99
 gi|22536545|ref|NP_687396.1|  hydrolase, haloacid dehalogena...   360   4e-98
 gi|76787060|ref|YP_329083.1|  Cof-like hydrolase [Streptococ...   359   9e-98
 gi|77409541|ref|ZP_00786225.1|  hydrolase, haloacid dehaloge...   357   3e-97
 gi|55822312|ref|YP_140753.1|  conserved hypothetical protein...   331   3e-89
 gi|71904129|ref|YP_280932.1|  hydrolase (HAD superfamily) [S...   330   5e-89
 gi|50914818|ref|YP_060790.1|  Hydrolase (HAD superfamily) [S...   330   5e-89
 gi|116627252|ref|YP_819871.1|  Predicted hydrolase of the HA...   330   6e-89
 gi|139473242|ref|YP_001127957.1|  putative haloacid dehaloge...   330   7e-89


InterPro Summary:  InterProScan

InterPro
IPR000150
Family
Cof protein
TIGR00099 [5-265]T 1.6732580256325697E-45 TIGR00099 Cof-subfamily Cof-subfamily
InterPro
IPR006379
Family
HAD-superfamily hydrolase, subfamily IIB
TIGR01484 [5-237]T 1.9162951626902204E-22 TIGR01484 HAD-SF-IIB HAD-SF-IIB
InterPro
IPR013200
Domain
HAD superfamily hydrolase-like, type 3
PF08282 [6-265]T 9.59995698566631E-70 PF08282 Hydrolase_3 Hydrolase_3
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.1000 [1-269]T 3.99998544139379E-43 G3DSA:3.40.50.1000 G3DSA:3.40.50.1000 G3DSA:3.40.50.1000
SSF56784 [1-270]T 3.1000000000000003E-56 SSF56784 SSF56784 SSF56784


COGS Summary:  COGS Search
BeTs to 11 clades of COG0561
COG name: Predicted hydrolases of the HAD superfamily
Functional Class: R
The phylogenetic pattern of COG0561 is a-tky-vCEBrH--GPOlin-
Number of proteins in this genome belonging to this COG is 11
Blocks Summary:  Blocks Search
***** IPB000150 (Cof protein) with a combined E-value of 8.3e-17.
    IPB000150A    2-16
    IPB000150B    36-45
    IPB000150C    216-248


 ProDom Summary:  Protein Domain Search
No significant hits to the ProDom database.

Paralogs:  Local Blast Search
SMu0367 is paralogously related (blast p-value < 1e-3) to SMu0675, SMu0388, SMu1012, SMu0655, SMu0674, SMu0461, SMu1666, SMu0442, and SMu1072, all conserved hypothetical proteins with some suggestion of hydrolase function.


Pfam Summary:  Pfam Search
Residues 3 to 241 (E-value = 3.3e-06) place SMu0367 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)

 Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MIKKMIAIDLDGTLLKSDGTLSDYTVAIIKKIQEQGHLVIITTGRPYRMA
LEFYKILGLKTPMINFNGSLIHIPEKKWAGEHKVRIDRRYLFDVLKNEKA
FEADFIASEYRKKFYLTLDHRHAIKPEIFGVKELTNKMQLKPEKITRDPH
ALLMQTRVADKYALANDMRRHFNHEMEISSWGGPMNILEFSPKGVHKAYA
LKNLLKTLNLSRDDLIAFGDEHNDRQMLAFASVGYAMKNASEVLLPYADK
MTQFDNDHDGVAKELKKLFL

Gene Nucleotide Sequence:  Sequence Viewer
ATGATTAAAAAAATGATTGCCATTGATTTAGATGGTACGCTTCTCAAAAG
TGACGGAACACTTTCCGATTACACTGTCGCTATTATTAAAAAAATTCAAG
AGCAAGGACACTTGGTTATCATTACGACTGGCCGGCCCTACCGTATGGCT
TTGGAATTTTATAAAATTCTAGGATTAAAAACACCAATGATTAATTTCAA
TGGTTCTTTGATTCACATTCCTGAGAAAAAATGGGCTGGTGAACACAAGG
TTCGGATTGACCGAAGGTATCTTTTTGACGTTTTAAAGAATGAAAAGGCC
TTTGAAGCAGACTTTATTGCCAGTGAATACCGCAAAAAATTTTACTTGAC
ACTTGATCACCGTCACGCCATTAAACCAGAGATTTTTGGTGTTAAAGAAT
TGACAAATAAGATGCAGCTTAAACCTGAAAAGATTACACGGGATCCCCAT
GCCCTTCTTATGCAGACCCGAGTTGCTGATAAATATGCTCTAGCTAATGA
TATGCGTCGCCATTTCAATCATGAAATGGAAATCAGCAGCTGGGGCGGCC
CTATGAATATCCTTGAATTTTCACCCAAAGGAGTTCACAAAGCTTATGCA
CTAAAAAATCTGCTCAAAACGCTCAATCTTTCTCGAGATGATTTAATAGC
CTTTGGTGATGAACATAACGATCGGCAAATGTTAGCCTTTGCTTCTGTCG
GCTATGCCATGAAAAATGCCAGTGAAGTACTGTTACCTTATGCTGATAAA
ATGACACAATTTGACAATGATCACGATGGCGTGGCTAAAGAACTAAAAAA
ATTGTTTCTATAG

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