[SBDD Membership Roster] [SBDD Meeting Rosters]

The Skeletal Biology Development and Disease [SBDD] study section reviews grant applications that deal with basic and translational aspects of normal and abnormal skeletal development. Specific areas covered by SBDD:

Bone Biology: Structural and organizational aspects of bone and cartilage including molecular and cellular biology, biochemistry, physiology and biomineralization with respect to osteoblasts, chondrocytes, connective tissue cells, osteoclasts and other cells in the marrow environment in both normal and pathological conditions.

• Basic and clinical studies of calcitropic hormones and paracrine factors involved in bone and cartilage biology; metabolic bone diseases, pathogenesis, and hormonal and paracrine functions.
• Extracellular matrix: biomineralization of the extracellular matrix of skeletal and connective tissues and its regulation; structure and organization of matrix components; cell matrix interaction and signaling.
• Studies involving diseases of the skeleton and mineral metabolism in humans and animal models such as osteogenesis imperfecta; Paget’s disease of bone; chondrodystrophies, osteodystrophies; diseases of mineral ion homeostasis associated with abnormalities of parathyroid hormone, Vitamin D, calcitonin and other hormonal and paracrine factors.
• Studies of molecular pathogenesis and biology of osteosarcoma, in vitro studies and animal models of the effects of primary tumors and metastasis to bone on function.

Skeletal Development: Mechanisms of craniofacial and skeletal patterning including gene discovery, gene expression and genetic linkage studies in human studies and animal models; biology of mesenchymal progenitor cells and their differentiation; regulation of osteoclast lineage; cellular proliferation, lineage commitment, differentiation, apoptosis and their abnormalities; and cellular aspects of aging of the skeleton using in vitro and in vivo models.

Study sections with most closely related areas of similar science listed in rank order are:

Skeletal Biology Structure and Regeneration [SBSR]
Development-2 [DEV2]
Arthritis Connective Tissue and Skin [ACTS]
Oral, Dental and Craniofacial Sciences [ODCS]
Neurological, Aging and Musculoskeletal Epidemiology [NAME]