Study Results & Research Projects

Summaries & Associations of Study Results

Levels from TR-550 Cresols (CAS No. 1319-77-3)

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Target Organs and Levels of Evidence for:

TR-550 Toxicology and Carcinogenesis Studies of Cresols (CAS No. 1319-77-3) in Male F344/N Rats and Female B6C3F1 Mice (Feed Studies)

Chemical (CAS Number)Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Cresols
1319-77-3		05/17/2007HOUSEHOLD DISINFECTANT, PAINTBRUSH CLEANER, IN LUBRICATING OILS, FUMIGANT, PHOTOGRAPHIC DEVELOPERS, EXPLOSIVES, ORGANIC INTERMEDIATE IN PROD'N OF COUMARIN, SALICYLALDEHYDE, SYNTHETIC RESINS, DEGREASING COMPOUNDS, OBTAINED FROM COAL TAR (HSDB 1990)Dosed-Feed
R: 0, 1500, 5000, OR 15,000 PPM AND M: 0, 1000, 3000, OR 10,000 PPM; 50/SPECIES/DOSE		Battelle Columbus Laboratory
Levels of Evidence
Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Kidney: Renal tubule adenoma (standard evaluation - 0/50, 0/50, 0/50, 3/50; standard and extended evaluations combined - 0/50, 0/50, 0/50, 4/50)
    • Non-Neoplastic Lesions
  • Liver: eosinophilic focus
  • Kidney: pelvis, transitional epithelium, hyperplasia; severity of nephropathy
  • Nasal Cavity: goblet cell, hyperplasia; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous; inflammation
    • Female Mice: Some Evidence
    TypeOrgan/Tissue (Lesion)
    Neoplastic Lesions
  • Forestomach: squamous cell papilloma (0/50, 1/50, 1/49, 10/50)
    • Non-Neoplastic Lesions
  • Liver: eosinophilic focus
  • Lung: bronchiole, hyperplasia
  • Thyroid gland: follicular degeneration
  • Nasal Cavity: respiratory epithelium, hyperplasia


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