Study Results & Research Projects

Summaries & Associations of Study Results

Levels from TR-548 Ethinyl Estradiol (CAS No. 57-63-6)

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Target Organs and Levels of Evidence for:

TR-548 Toxicology and Carcinogenesis Study of Ethinyl Estradiol (CAS No. 57-63-6) in Sprague-Dawley Rats (Feed Studies)

Chemical (CAS Number) Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Endocrine disruptor (Ethinyl estradiol)
57-63-6 		05/16/2007 NONSTEROIDAL SEMI-SYNTHETIC ESTROGEN USED IN THE TREATMENT OF BREAST AND PROSTATE CANCER Dosed-Feed National Center for Toxicological Research
Levels of Evidence
F1C Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Mammary gland: alveolar hyperplasia (1/44, 4/45, 6/47, 18/44); ductal hyperplasia (0/44, 0/45, 2/47, 3/44)
  • Liver: basophilic focus (1/49, 3/49, 3/50, 17/49); eosinophilic focus (3/49, 5/49, 8/50, 15/49)
    		•
    F1C Female Rats: No Evidence
    Type Organ/Tissue (Lesion)
    Non-Neoplastic Lesions
  • Uterus: endometrial hyperplasia (17/51, 18/50, 22/49, 25/50); squamous metaplasia (2/51, 6/50, 8/49, 13/50); atypical focal hyperplasia (6/51, 14/50, 16/49, 20/50)
  • Liver: eosinophilic focus (1/51, 1/50, 1/49, 5/50)
    		•
    F1T140 Male Mice: No Evidence
    Type Organ/Tissue (Lesion)
    Non-Neoplastic Lesions
  • Mammary gland: alveolar hyperplasia (1/44, 2/45, 6/47, 14/48); ductal hyperplasia (0/44, 0/45, 1/47, 3/48)
  • Liver: basophilic focus (1/49, 3/50, 11/48, 6/49); eosinophilic focus (3/49, 11/50, 5/48, 10/49)
    		•
    F1T140 Female Mice: Equivocal evidence
    Type Organ/Tissue (Lesion)
    Non-Neoplastic Lesions
  • Liver: basophilic focus (1/51, 1/50, 1/50, 6/50)
  • Clitoral gland: hyperplasia (2/50, 1/50, 2/49, 8/49)
    		•
    May Have Been Related
  • Uterus/Cervix: stromal polyp (2/51, 5/50, 6/50, 7/50)
    		•
    F3T21 Male Mice: Some Evidence
    Type Organ/Tissue (Lesion)
    Neoplastic Lesions
  • Preputial Gland: epithelial neoplasms (2/49, 4/49, 4/50, 8/49)
    		•
    Non-Neoplastic Lesions
  • Mammary gland: alveolar hyperplasia (2/42, 6/42, 4/40, 9/45)
    		•
    May Have Been Related
  • Mammary Gland: adenoma or adenocarcinoma (0/42, 0/42, 0/40, 3/45)
    		•
    F3T21 Female Mice: Equivocal evidence
    Type Organ/Tissue (Lesion)
    Non-Neoplastic Lesions
  • Uterus: squamous metaplasia (1/52, 4/50, 3/50, 11/50); atypical focal hyperplasia (6/52, 16/50, 15/50, 21/50)
  • Clitoral gland: hyperplasia (0/50, 1/50, 2/49, 3/48)
    		•
    May Have Been Related
  • Uterus/Cervix: stromal polyp (1/52, 7/50, 2/50, 5/50)
    		•


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    Web page last updated on January 28, 2008