National Toxicology Program

CASRN: TEFBINARYMIX

Formula: N/A

Synonyms/Common Names:

• BINARY MIXTURE (TOXIC EQUIVALENCY FACTOR EVALUATION)
• TOXIC EQUIVALENCY FACTOR EVALUATION (BINARY MIXTURE)

Secondary:

• 35065-27-1 - 2,2'-4,4',5,5'-Hexachlorobiphenyl (PCB 153)
• 57465-28-8 - 3,3,4,4,5-Pentachlorobiphenyl
• 57465-28-8 - TEF transgenics (PCB 126)
• 35065-27-1 - Toxic equivalency factor evaluation (PCB 153- 2,2'-4,4',5,5'-hexachlorobiphenyl)
• 57465-28-8 - Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl)

Known Uses:

ONE OF 2 MIXTURES BEING TESTED ALONG WITH 5 DIOXIN-LIKE COMPOUNDS TO DETERMINE IF THE TOXIC EQUIVALENCY FACTORS (TEFS) FOR THESE CHEMICALS WOULD BE PREDICTIVE OF RODENT CARCINOGENICITY. THIS MIXTURE CONSISTS OF TCDD, PENTACHLORODIBENZO-P-DIOXIN, PEN

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C96020) Report Complete 
  • TR-530 (NTIS No. PB2008109743)  (Peer Review 12/09/2004)
    Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) and 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
  • Rats: Sprague Dawley
  • Carcinogenesis Results
  • Female Rats Clear Evidence 
  • Dose: FEMALE RATS ONLY: 0; (PCB126) 10, 100, 300, OR 1000 NG/KG; (PCB 153) 10, 100, 300, OR 1000 UG/KG; 50/DOSE