National Toxicology Program

CASRN: 1746-01-6

Related: TCDD & TRANSGENIC MODEL EVALUATION

Formula: C12 H4 C14 O2

Synonyms/Common Names:

• TCDD (TOXIC EQUIVALENCY FACTOR EVALUATION)
• TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)
• TOXIC EQUIVALENCY FACTOR EVALUATION (2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN)

Known Uses:

ONE OF 5 DIOXIN-LIKE COMPOUNDS PLUS 2 MIXTURES BEING TESTED TO DETERMINE IF THE TOXIC EQUIVALENCY FACTORS (TEFS) FOR THESE CHEMICALS WOULD BE PREDICTIVE OF RODENT CARCINOGENICITY.

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C96007G) Report Complete 
  • TR-521 (NTIS No. PB 2006-112291)  (Peer Review 02/17/2004)
    Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
  • Rats: Sprague Dawley
  • Carcinogenesis Results
  • Female Rats Clear Evidence 
  • Dose: FEMALE RATS ONLY: TCDD -- 0, 3, 10, 22, 46, OR 100 NG/KG; 100/DOSE