National Toxicology Program

CASRN: 446-72-0

Formula: C15 H10 O5

Synonyms/Common Names:

• 4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)- (9CI)
• GENISTEIN (ENDOCRINE DISRUPTOR)

Known Uses:

ANTINEOPLASTIC AGENT; GROWTH INHIBITOR; NATURALLY-OCCURRING PHYTOESTROGEN FOUND IN SEVERAL PLANTS INCLUDING SOY PRODUCTS. NUTRITIONAL AND PHARMACEUTICAL APPLICATIONS.

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C99040) Report Review 
  • TR-545   (Peer Review 06/12/2006)
    Toxicology and Carcinogenesis Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (feed study)
  • Rats: Sprague Dawley; Rats: Sprague Dawley; Rats: Sprague Dawley
  • Carcinogenesis Results
  • In Utero and continuing for 2 years:
  • Male Rats = No Evidence
  • Female Rats = Some Evidence
  • In Utero and continuing for 20 weeks:
  • Male Rats = No Evidence
  • Female Rats = Equivocal Evidence
  • In Utero and continuing for Post Natal Day 21:
  • Male Rats = No Evidence
  • Female Rats = Equivocal Evidence
  • Dose: 0, 5, 100, 500 PPM

Organ Systems Toxicity

• Multigenerational Screen (Dosed-Feed)  (MG96005) Completed 
  • Citation: Multigenerational Reproductive Toxicology Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (feed study)
  • M/F Rats: Sprague Dawley
  • Reproductive Dose Range Finding (Completed)
    • Days of Treatment: 28 DAYS
    • Dose: 0, 5, 25, 100, 250, 625, OR 1250 PPM
  • Immunotoxicity (Completed)
    • Days of Treatment: 4 WEEKS
    • Dose: 0, 5, 25, 100, 250, 625, OR 1250 PPM
  • Behavioral Toxicity (Completed)
    • Days of Treatment: 10 WEEKS
    • Dose: 0, 25, 250, OR 1250 PPM
  • Multigeneration Reproductive Study (F0) (Completed)
    • Days of Treatment: 20 WEEKS
    • Dose: 0, 5, 100, OR 250 PPM
  • Multigeneration Reproductive Study (F1) (Completed)
    • Days of Treatment: 20 WEEKS
    • Dose: 0, 5, 100, OR 250 PPM
  • Multigeneration Reproductive Study (F2) (Completed)
    • Days of Treatment: 20 WEEKS
    • Dose: 0, 5, 100, OR 250 PPM
  • Multigeneration Reproductive Study (F3) (Completed)
    • Days of Treatment: 20 WEEKS
    • Dose: 0, 5, 100, OR 250 PPM
  • Multigeneration Reproductive Study (F4) (Completed)
    • Days of Treatment: 20 WEEKS
    • Dose: 0, 5, 100, OR 250 PPM
  • Cancer Study (F1) (Completed)
    • Days of Treatment: 2 YEARS
    • Dose: 0, 5, 100, OR 250 PPM
  • Cancer Study (F3) (Completed)
    • Days of Treatment: 2 YEARS
    • Dose: 0, 5, 100, OR 250 PPM