National Toxicology Program

CASRN: 6533-68-2

Related: SCOPOLAMINE HYDROBROMIDE (114-48-8)

Formula: C17 H21 N O4.BR-H.3H2-O

Synonyms/Common Names:

• BENZENEACETIC ACID, ALPHA-(HYDROXYMETNYL)-,9-METHYL-3-OXA-9-AZATRICYCLO(3.3.1.0(2,4))NON-7-YL ESTER, HYDROBROMIDE, TRIHYDRATE, (7(S)-(1ALPHA,2BETA,4BETA,5ALPHA,7BETA))- (9CI)
• HYOSCINE HYDROBROMIDE

Known Uses:

ANTICHOLINERGIC; TREATMENT OF MOTION SICKNESS

Short-Term Toxicity

• 14-Day (Gavage)  (C03098A) Completed 
  • NTIS No. PB97-208946
    Citation: Toxicology and Carcinogenesis Studies of Scopolamine Hydrobromide Trihydrate (CAS No. 6533-68-2) in F344 Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 14-Day (Dosed-Water)  (C03098B) Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C03098A) Completed 
  • NTIS No. PB97-208946
    Citation: Toxicology and Carcinogenesis Studies of Scopolamine Hydrobromide Trihydrate (CAS No. 6533-68-2) in F344 Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,15,1200 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2&3-YEAR (Gavage)  (C03098C) Report Complete 
  • TR-445 (NTIS No. PB97-208946)  (Peer Review 06/20/1995)
    Toxicology and Carcinogenesis Studies of Scopolamine Hydrobromide Trihydrate (CAS No. 6533-68-2) in F344 Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R&M: 0,1,5, OR 25 MG/KG; 70/GROUP DIET RESTRICTION MICE: 0 OR 25 MG/KG;70/GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (243331) Completed 
  • Chromosome Aberation Weakly Positive 
  • Sister Chromatid Exchange Negative 
• Salmonella  (907250) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Negative