National Toxicology Program

CASRN: 119-61-9

Formula: C13 H10 O

Synonyms/Common Names:

• METHANONE, DIPHENYL- (9CI)

Known Uses:

ODOR FIXATIVE. IN MANUFACTURE OF ANTIHISTAMINES, HYPNOTICS, INSECTICIDES, PERFUMES (MERCK 1989). CHEMICAL INTERMEDIATE, PHOTOINITIATOR.

Nomination Background

Short-Term Toxicity

• 13-WEEK (Dosed-Feed)  (C88138) Report Complete 
  • TOX-61   (Peer Review 10/00/1999)   (Toxicity Peer Review 08/00/1999)
    Toxicity Studies of Benzophenone Administered in Feed to F344/N Rats and B6C3F1Mice (CAS No. 119-61-9)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0,0.125,0.25,0.5,1.0,2.0 %; R: 20/SEX/GRP; M: 10/SEX/GRP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C88138B) Report Complete 
  • TR-533 (NTIS No. PB2006-111481)  (Peer Review 12/09/2004)
    Toxicology and Carcinogenesis Studies of Benzophenone (CAS No. 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice Some Evidence 
  • Female Mice Some Evidence 
  • Dose: R&M: 0, 312, 625, OR 1250 PPM; 50/SEX/DOSE

Special Studies

• Toxicokinetic Study (Intravenous; Gavage; Dosed-Feed)  (S0592) Completed 
  • M/F Rats: F344; M/F Mice: B6C3F1; M/F Rats: F344; M/F Mice: B6C3F1; M/F Rats: F344; M/F Mice: B6C3F1
  • Dose: PRELIM: Rat: iv: 2.5 mg/kg, gavage: 2.5 and 10 mg/kg mice: iv: 15 mg/kg, gavage: 15 and 60 mg/kg TK study: feed: 312 & 1250ppm for both; iv: 2.5 mg/kg(rat), 15mg/kg(mouse); and gavage: 2.5, 5, 10 mg/kg(rat) and 15, 30, 60mg/kg(mouse)

Genetic Toxicology

• Micronucleus  (A27713) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A83002) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (237060) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 

Organ Systems Toxicity

• GD 6-19 Conventional Teratology (Gavage)  (TER98005) Completed 
  • NTIS No. PB2003-101281
    Citation: Final Study Report Developmental Toxicity Evaluation for Benzophenone (Cas No. 119-61-9) Administered by Gavage to Sprague-Dawley (CD®) Rats on Gestational Days 6 through 19
  • NTIS No. PB2003-101282
    Citation: Final Study Report Developmental Toxicity Evaluation for Benzophenone (Cas No. 119-61-9) Administered by Gavage to Sprague-Dawley (CD®) Rats on Gestational Days 6 through 19
  • F Rats: Sprague Dawley
  • Dose: 0, 100, 200 OR 300 MG/KG/DAY
• GD 6-29 Conventional Teratology (Gavage)  (TER99001) Completed 
  • NTIS No. PB2004105387
    Citation: FINAL STUDY REPORT  DEVELOPMENTAL TOXICITY EVALUATION FOR BENZOPHENONE (CAS NO. 119-61-9) ADMINISTERED BY GAVAGE TO NEW ZEALAND WHITE RABBITS ON GESTATIONAL DAYS 6 THROUGH 29
  • NTIS No. PB2004105388
    Citation: FINAL STUDY REPORT  DEVELOPMENTAL TOXICITY EVALUATION FOR BENZOPHENONE (CAS NO. 119-61-9) ADMINISTERED BY GAVAGE TO NEW ZEALAND WHITE RABBITS ON GESTATIONAL DAYS 6 THROUGH 29 (Laboratory Supplement)
  • F Rabbit: New Zealand White
  • Dose: 0, 5, 25, AND 45 MG/KG/DAY
• GD 6 THROUGH 15 Teratology Pilot Studies (Gavage)  (TRP92053) Completed 
  • F Rats: Sprague Dawley
  • Dose: 0, 200, 400, 600, 800, OR 1000 MG/KG
• GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)  (TRP92062) Completed 
  • F Rabbit: New Zealand White
  • Dose: 0, 100, 200, 400, 600, OR 800 MG/KG
• GD 6-19 Teratology Pilot Studies (Gavage)  (TRP98005) Completed 
  • F Rats: Sprague Dawley
  • Dose: 0, 25, 50, 100, 200, OR 300 MG/KG/DAY
• GD 6-29 Teratology Pilot Studies (Gavage)  (TRP99001) Completed 
  • F Rabbit: New Zealand White
  • Dose: 0, 25, 50, 75, 100, OR 125 MG/KG/DAY