Testing Information

Testing Status of Agents at NTP

Isophosphamide

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http://ntp.niehs.nih.gov/go/TS-C01638

CASRN: 3778-73-2

Formula: C7-H15-CL2-N2-O2-P

Synonyms/Common Names:

  • N,3-BIS(2-CHLOROETHYL)TETRAHYDRO-2H,1,3,2-OXAZAPHOSPHARIN-2-AMINE,2-OXIDE (9CI)

Known Uses:

ANTICANCER AGENT

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01638) Completed 
    • NTIS No. PB275677  (Peer Review 09/26/1977)
      Citation: Bioassay of Isophosphamide for Possible Carcinogenicity (CAS No. 3778-73-2)
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01638) Completed 
    • NTIS No. PB275677  (Peer Review 09/26/1977)
      Citation: Bioassay of Isophosphamide for Possible Carcinogenicity (CAS No. 3778-73-2)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: MR: 0,2.4,48, MM: 0,4,80 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01638) Report Complete 
    • TR-032 (NTIS No. PB275677)  (Peer Review 09/26/1977)
      Bioassay of Isophosphamide for Possible Carcinogenicity (CAS No. 3778-73-2)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Positive 
    • Dose: R: 0,6,12, M: 0,10,20 MG/KG/35 PER GROUP

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Web page last updated on November 24, 2008