Testing Information

Testing Status of Agents at NTP

Captan

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http://ntp.niehs.nih.gov/go/TS-C00077

CASRN: 133-06-2

Formula: C9-H8-CL3-N-O2-S

Synonyms/Common Names:

  • FLIT 406

Known Uses:

FUNGICIDE, BACTERIOSTAT IN SOAP (MERCK 1989)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00077) Completed 
    • NTIS No. PB273475  (Peer Review 07/25/1977)
      Citation: Bioassay of Captan for Possible Carcinogenicity (CAS No. 133-06-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00077) Completed 
    • NTIS No. PB273475  (Peer Review 07/25/1977)
      Citation: Bioassay of Captan for Possible Carcinogenicity (CAS No. 133-06-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: 0,500,32000 PPM/5 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00077) Report Complete 
    • TR-015 (NTIS No. PB273475)  (Peer Review 07/25/1977)
      Bioassay of Captan for Possible Carcinogenicity (CAS No. 133-06-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,2525,6050 (AVG), M: 0,8000,16000 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (985028) Completed 
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Salmonella  (162568) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

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Web page last updated on November 24, 2008