National Toxicology Program

CASRN: 84-65-1

Formula: C14-H8-O2

Synonyms/Common Names:

• 9,10-ANTHRACENEDIONE (9CI)

Known Uses:

INTERMEDIATE IN MANUFACTURE OF DYES AND OTHER ORGANICS. ORGANIC INHIBITOR. CATALYST. ACCELERATOR IN NICKEL ELECTROPLATING. IMPROVING ADHESION AND HEAT STABILITY OF TIRE CORD. (NTP EXECUTIVE SUMMARY)

Short-Term Toxicity

• 4-WEEK (Dosed-Feed)  (C88036) Completed 
  • NTIS No. PB2006-101509  (Peer Review 12/09/2004)
    Citation: Toxicology and Carcinogenesis Studies of Anthraquinone (CAS No. 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N
  • Dose: R: 0, 469, 938 OR 3750 PPM; 20/SEX/GROUP
• 13-WEEK (Dosed-Feed)  (C88036) Completed 
  • NTIS No. PB2006-101509  (Peer Review 12/09/2004)
    Citation: Toxicology and Carcinogenesis Studies of Anthraquinone (CAS No. 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 1875, 3750, 7500, 15000, OR 30000 PPM; R: 20/SEX/GROUP M: 10/SEX/GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C88036) Report Complete 
  • TR-494 (NTIS No. PB2006-101509)  (Peer Review 12/09/2004)
    Toxicology and Carcinogenesis Studies of Anthraquinone (CAS No. 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Clear Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: R: 0, 469, 938, 1875, OR 3750 PPM M: 0, 833, 2500, OR 7500 PPM

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage)  (S0182) Completed 
  • M Rats: F344
  • Dose: 0.35, 3.5, 35, 350 MG/KG
• Toxicokinetic Study (Intravenous; Gavage; Intravenous; Gavage)  (S0558) Completed 
  • Citation: SEE TECHNICAL REPORT 494
  • Rats: F344; Rats: F344; Mice: B6C3F1; Mice: B6C3F1
  • Dose: SINGLE ADMINSTRATION RECORD: PRELIM: IV 4 MG/KG MICE & 2 MG/KG RAT; GAV 80 & 80 0 MG/KG MICE & 40 & 400 MG/KG RAT

Genetic Toxicology

• Micronucleus  (404278) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A47616) Completed 
  • Mice: B6C3F1
  • Male Positive 
  • Female Positive 
• Salmonella  (480416) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Positive 
• Salmonella  (A07496) Completed 
  •  Negative 
• Salmonella  (A40147) Completed 
  •  Positive 
• Salmonella  (A48640) Completed 
  •  Negative 
• Salmonella  (A54984) Completed 
  •  Negative 
• Salmonella  (A65343) Completed 
  •  Negative