Testing Information

Testing Status of Agents at NTP

1,2-Dichloroethane

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http://ntp.niehs.nih.gov/go/TS-10962-L

CASRN: 107-06-2

Formula: C2-H4-CL2

Synonyms/Common Names:

  • ETHYLENE DICHLORIDE
  • ETHYLENE DICHLORIDE (EDC)

Known Uses:

PRODUCTION OF VINYL CHLORIDE AND OTHER CHLORINATED CHEMICALS; LEAD SCAVENGER; FUMIGANT; SOLVENT FOR PHARMACEUTICAL PRODUCTS, UPHOLSTERY AND CARPET CLEANER, RUBBER GOODS (HSDB 1990)

Nomination Background

Short-Term Toxicity

  • 14-Day (Gavage)  (C00511A) Completed 
    • NTIS No. PB285968  (Peer Review 03/06/1978)
      Citation: Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity (CAS No. 107-06-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C00511A) Completed 
    • NTIS No. PB285968  (Peer Review 03/06/1978)
      Citation: Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity (CAS No. 107-06-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0,40,251, M: 0,159,1000 MG/KG/5 PER GROUP
  • 13-WEEK (Gavage)  (C00511B) Report Complete 
    • TOX-04 (NTIS No. PB91-185363)  (Peer Review 06/27/1989)
      Toxicity Studies of 1,2-Dichloroethane (Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-Mendel Rats, and B6C3F1Mice (Drinking Water and Gavage Studies) (CAS No. 107-06-2)
    • Rats: F344/N
    • Dose: MR: 0, 30, 60, 120, 240, 480; FR: 0, 20, 40, 75, 150, 300 MG/KG/10 PER GROUP
  • 13-WEEK (Dosed-Water)  (C00511C) Report Complete 
    • TOX-04 (NTIS No. PB91-185363)  (Peer Review 06/27/1989)
      Toxicity Studies of 1,2-Dichloroethane (Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-Mendel Rats, and B6C3F1Mice (Drinking Water and Gavage Studies) (CAS No. 107-06-2)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 500, 1000, 2000, 4000, 8000 PPM (10 PER GROUP)
  • 13-WEEK (Dosed-Water)  (C00511D) Report Complete 
    • TOX-04 (NTIS No. PB91-185363)  (Peer Review 06/27/1989)
      Toxicity Studies of 1,2-Dichloroethane (Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-Mendel Rats, and B6C3F1Mice (Drinking Water and Gavage Studies) (CAS No. 107-06-2)
    • Rats: Sprague Dawley; Rats: Osborne Mendel
    • Dose: R: 0, 500, 1000, 2000, 4000, 8000 PPM (10 PER GROUP)

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C00511A) Report Complete 
    • TR-055 (NTIS No. PB285968)  (Peer Review 03/06/1978)
      Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity (CAS No. 107-06-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,47,95 (AVG), MM: 0,97,195 (AVG), FM: 0,149,299 (AVG) MG/KG/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (756073) Completed 
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Micronucleus  (A32670) Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (446462) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

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Web page last updated on November 24, 2008