National Toxicology Program

CASRN: 8001-35-2

Formula: C10 H8 CL8

Synonyms/Common Names:

• CAMPHECHLOR

Known Uses:

INSECTICIDE

Nomination Background

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00259) Completed 
  • NTIS No. PB292290  (Peer Review 08/31/1978)
    Citation: Bioassay of Toxaphene for Possible Carcinogenicity (CAS No. 8001-35-2)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00259) Completed 
  • NTIS No. PB292290  (Peer Review 08/31/1978)
    Citation: Bioassay of Toxaphene for Possible Carcinogenicity (CAS No. 8001-35-2)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,160,2560 (AVG), M: 0,40,1280 (AVG) PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00259) Report Complete 
  • TR-037 (NTIS No. PB292290)  (Peer Review 08/31/1978)
    Bioassay of Toxaphene for Possible Carcinogenicity (CAS No. 8001-35-2)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal 
  • Female Rats Equivocal 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: MR: 0,556,1112 (AVG), FR: 0,540,1080 (AVG), M: 0,99,198 (AVG) PPM/50 PER GROUP

Genetic Toxicology

• Salmonella  (907413) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Positive