National Toxicology Program

CASRN: 79-34-5

Related: HALOGENATED ETHANES CS (1,1,2,2-TETRACHLOROETHANE)

Formula: C2 H2 CL4

Synonyms/Common Names:

• ACETYLENE TETRACHLORIDE
• ACETYLENETETRACHLORIDE
• TCE

Known Uses:

SOLVENT; SOIL STERILIZATION; HERBICIDES; INSECTICIDES; PAINTS; VARNISH; METAL CLEANERS AND DEGREASERS

Nomination Background

Short-Term Toxicity

• 14-Day (Gavage)  (C03554A) Completed 
  • NTIS No. PB277453  (Peer Review 09/26/1977)
    Citation: Bioassay of 1,1,2,2-Tetrachloroethane for Possible Carcinogenicity (CAS No. 79-34-5)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 2-WEEK (Microencapsulation in Feed)  (C03554B) Report Review 
  • TOX-49   (Toxicity Peer Review 05/23/2002)
    Toxicity Studies of 1,1,2,2-Tetrachloroethane Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice (CAS No. 79-34-5)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 3325, 6650, 13300, 26600, OR 53200 PPM (5/SEX/SPECIES/GROUP)
• 2-WEEK (Gavage)  (C03554C) Completed 
  • TOX-49 
    Toxicity Studies of 1,1,2,2-Tetrachloroethane Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice (CAS No. 79-34-5)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 135, 270, OR 540 MG/KG M: 0, 337.5, 675, OR 1350 MG/KG (50/SEX/SPECIES)
• 13-Week (Gavage)  (C03554A) Completed 
  • NTIS No. PB277453  (Peer Review 09/26/1977)
    Citation: Bioassay of 1,1,2,2-Tetrachloroethane for Possible Carcinogenicity (CAS No. 79-34-5)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,56,562, M: 0,32,136 MG/KG/10 PER GROUP
• 14-WEEK (Microencapsulation in Feed)  (C03554E) Report Complete 
  • TOX-49   (Toxicity Peer Review 05/23/2002)
    Toxicity Studies of 1,1,2,2-Tetrachloroethane Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice (CAS No. 79-34-5)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: UNTREATED CONTROLS; VEHICLE CONTROLS; 268, 589, 1180, 2300 OR 4600 PPM (RATS) OR 589, 1120, 2300, 4550 OR 9100 PPM (MICE) 10/SEX/SPECIES/GROUP.

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C03554A) Report Complete 
  • TR-027 (NTIS No. PB277453)  (Peer Review 09/26/1977)
    Bioassay of 1,1,2,2-Tetrachloroethane for Possible Carcinogenicity (CAS No. 79-34-5)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal 
  • Female Rats Negative 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: FR: 0,43,76 (AVG), MR: 0,62,108 (AVG), M: 0,142,284 (AVG) MG/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (838914) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Drosophila  (959130) Completed 
  • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (990809) Completed 
  •  Negative 
• Micronucleus  (A72450) Completed 
  • Mice: B6C3F1
  • Male Positive 
  • Female Positive 
• Micronucleus  (B72450) Completed 
  • Mice: B6C3F1
  • Male Inconclusive 
  • Female Positive 
• Salmonella  (547949) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Salmonella  (866388) Completed 
  •  Negative 

Organ Systems Toxicity

• Teratology Pilot Studies (Dosed-Feed)  (TRP91023) Completed 
  • F Mice: Swiss CD-1
  • Dose: 0, 4, 7.5, 10.%
• GD 6 THROUGH 16 Teratology Pilot Studies (Dosed-Feed)  (TRP91028) Completed 
  • F Mice: Swiss CD-1
  • Dose: 0, .0125, .05, .1, .2, OR .3 %
• GD 6 THROUGH 16 Teratology Pilot Studies (Dosed-Feed)  (TRP91029) Completed 
  • F Rats: Sprague Dawley
  • Dose: 0, 0.045, 0.135, 0.270, 0.405, OR 0.540%
• GD 6 THROUGH 15 Teratology Pilot Studies (Dosed-Feed)  (TRP91069) Completed 
  • F Mice: Swiss CD-1
  • Dose: 0, .5, 1, 1.5, 2, OR 3%
• Teratology Pilot Studies (Gavage)  (TRP92039) Completed 
  • Rabbit: New Zealand White
  • Dose: 0,10,50,100,150,200 MG/KG
• Teratology Pilot Studies (Gavage)  (TRP92064) Completed 
  • Rats
  • Dose: 0, 100, 150, 200, 250 MG/KG