National Toxicology Program

CASRN: 129-15-7

Formula: C15-H9-N-O4

Synonyms/Common Names:

• 2-METHYL-1-NITRO-9,10-ANTHRACENEDIONE (9CI)

Known Uses:

DYE INTERMEDIATE (FORMERLY)SYN

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C01923A) Completed 
  • NTIS No. PB277439  (Peer Review 11/28/1977)
    Citation: Bioassay of 2-Methyl-1-Nitroanthraquinone for Possible Carcinogenicity (CAS No. 129-15-7)
  • Rats: F344/N; Mice: B6C3F1
• 2-WEEK (Dosed-Feed)  (C01923B) Completed 
  •   (Peer Review 11/18/1977) Citation: ASK Murthy, JR Baker, ER Smith, GG Wade, Development of Hemangiosarcomas in B6C3F1 Mice Fed 2-Methyl-1-Nitroanthraquinone. Int. J. Cancer 19:117-121 (1977)
  • Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C01923A) Completed 
  • NTIS No. PB277439  (Peer Review 11/28/1977)
    Citation: Bioassay of 2-Methyl-1-Nitroanthraquinone for Possible Carcinogenicity (CAS No. 129-15-7)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,0.005,5 %/5 PER GROUP
• 13-WEEK (Dosed-Feed)  (C01923B) Completed 
  •   (Peer Review 11/18/1977) Citation: ASK Murthy, JR Baker, ER Smith, GG Wade, Development of Hemangiosarcomas in B6C3F1 Mice Fed 2-Methyl-1-Nitroanthraquinone. Int. J. Cancer 19:117-121 (1977)
  • Mice: B6C3F1

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C01923A) Report Complete 
  • TR-029 (NTIS No. PB277439)  (Peer Review 11/28/1977)
    Bioassay of 2-Methyl-1-Nitroanthraquinone for Possible Carcinogenicity (CAS No. 129-15-7)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: 0,0.06,0.12 %/50 PER GROUP
• 2-YEAR (Dosed-Feed)  (C01923B) Report Complete 
  •   (Peer Review 11/18/1977) Citation: ASK Murthy, JR Baker, ER Smith, GG Wade, Development of Hemangiosarcomas in B6C3F1 Mice Fed 2-Methyl-1-Nitroanthraquinone. Int. J. Cancer 19:117-121 (1977)
  • Mice: B6C3F1
  • Dose: 0,.05,.15,.5,1.5,5.0 %

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (565805) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (693002) Completed 
  • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Salmonella  (324967) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Positive