National Toxicology Program

CASRN: 58-89-9

Formula: C6-H6-CL6

Synonyms/Common Names:

• GAMA-HCH
• (1ALPHA,2ALPHA,3BETA,4ALPHA,5ALPHA,6BETA)-1,2,3,4,5,6-HEXACHLORO-CYCLOHEXANE (9CI)

Known Uses:

INSECTICIDE, PEDICULICIDE, SCABICIDE (MERCK 1989)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00204) Completed 
  • NTIS No. PB273480  (Peer Review 07/25/1977)
    Citation: Bioassay of Lindane for Possible Carcinogenicity (CAS No. 58-89-9)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00204) Completed 
  • NTIS No. PB273480  (Peer Review 07/25/1977)
    Citation: Bioassay of Lindane for Possible Carcinogenicity (CAS No. 58-89-9)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,160,2560, M: 0,40,1280 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00204) Report Complete 
  • TR-014 (NTIS No. PB273480)  (Peer Review 07/25/1977)
    Bioassay of Lindane for Possible Carcinogenicity (CAS No. 58-89-9)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: MR: 0,236,472 (AVG), FR: 0,135,270 (AVG), M: 0,80,160 PPM/50 PER GROUP

Special Studies

• C. elegans  (S0929) Completed 
  • Nematode: C. elegans
  • Dose: feed (0,.025,.032,.04,.05,.063,.079,.1,.13,.16,.20,.25) mM 11/02/06 repro (0,.01,.016,.025,.04,.063,.1,.16,.25,.4,.63,1) mM 02/23/06 GROWTH: (0,.01,.016,.025,.04,.063,.1,.16,.25,.4,.63,1) mM 06/27/07

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (931320) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (849017) Completed 
  •  Inconclusive 
• Salmonella  (946710) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative