National Toxicology Program

CASRN: 13552-44-8

Formula: C13-H14-N2.2CL-H

Synonyms/Common Names:

• 4,4'-METHYLENEBISBENZENAMINE DIHYDROCHLORIDE (9CI)

Known Uses:

INTERMEDIATE FOR ISOCYANATES AND POLYISOCYANATES

Short-Term Toxicity

• 14-Day (Dosed-Water)  (C54604) Completed 
  • NTIS No. PB83-238824  (Peer Review 06/16/1982)
    Citation: Carcinogenesis Studies of 4,4'-Methylenedianiline Dihydrochloride (CAS No. 13552-44-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Water)  (C54604) Completed 
  • NTIS No. PB83-238824  (Peer Review 06/16/1982)
    Citation: Carcinogenesis Studies of 4,4'-Methylenedianiline Dihydrochloride (CAS No. 13552-44-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,50,800, M: 0,25,400 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Water)  (C54604) Report Complete 
  • TR-248 (NTIS No. PB83-238824)  (Peer Review 06/16/1982)
    Carcinogenesis Studies of 4,4'-Methylenedianiline Dihydrochloride (CAS No. 13552-44-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: 0,150,300 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (204381) Completed 
  • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (589444) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Negative 
• Mouse Lymphoma  (641032) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Salmonella  (735526) Completed 
  •  Positive 
• Salmonella  (786789) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Positive