National Toxicology Program

CASRN: 6358-85-6

Formula: C32 H26 N6 O4 CL2

Synonyms/Common Names:

• C. I. PIGMENT YELLOW 12
• 2,2'-((3,3'-DICHLORO(1,1'-BIPHENYL)-4,4'-DIYL)BIS(AZO))BIS(3-OXO-N-PHENYL-BUTANAMIDE) (9CI)
• YELLOW 12, C.I. PIGMENT

Known Uses:

DYE FOR PAINT, INK, PLASTIC, RUBBER

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03269) Completed 
  • NTIS No. PB278272  (Peer Review 09/26/1977)
    Citation: Bioassay of Diarylanilide Yellow for Possible Carcinogenicity (CAS No. 6358-85-6)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03269) Completed 
  • NTIS No. PB278272  (Peer Review 09/26/1977)
    Citation: Bioassay of Diarylanilide Yellow for Possible Carcinogenicity (CAS No. 6358-85-6)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,.1,3.0, M: 0,.03,3.0 %/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03269) Report Complete 
  • TR-030 (NTIS No. PB278272)  (Peer Review 09/26/1977)
    Bioassay of Diarylanilide Yellow for Possible Carcinogenicity (CAS No. 6358-85-6)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,2.5,5 %/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (659162) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Inconclusive 
• Mouse Lymphoma  (566314) Completed 
  •  Negative 
• Salmonella  (983137) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative 
• Salmonella Reduction  (637663) Completed 
  • Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
  •  Negative