Testing Information

Testing Status of Agents at NTP

2,4-Dimethoxyaniline hydrochloride

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http://ntp.niehs.nih.gov/go/TS-10797-V

CASRN: 54150-69-5

Related: 2,4-DIMETHOXYANILINE (CAS 2735-04-8)

Formula: C8 H11 N O2.H CL

Synonyms/Common Names:

  • 2,4-DIMETHOXYBENZENAMINE HYDROCHLORIDE (9CI)

Known Uses:

SALT OF 2,4-DIMETHOXYANILINE; DYE INTERMEDIATE; NOT USED COMMERCIALLY

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02255) Completed 
    • NTIS No. PB288625  (Peer Review 08/31/1978)
      Citation: Bioassay of 2,4-Dimethoxyaniline Hydrochloride for Possible Carcinogenicity (CAS No. 54150-69-5)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02255) Completed 
    • NTIS No. PB288625  (Peer Review 08/31/1978)
      Citation: Bioassay of 2,4-Dimethoxyaniline Hydrochloride for Possible Carcinogenicity (CAS No. 54150-69-5)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,2150,21600, M: 0,3160,31500 PPM/5 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C02255) Report Complete 
    • TR-171 (NTIS No. PB288625)  (Peer Review 08/31/1978)
      Bioassay of 2,4-Dimethoxyaniline Hydrochloride for Possible Carcinogenicity (CAS No. 54150-69-5)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,1500,3000, M: 0,2500,5000 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (434745) Completed 
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Mouse Lymphoma  (832423) Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    •  Positive 
  • Micronucleus  (756856) Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella (NCI)  (N-9379) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella-NCI  Positive 
  • Salmonella  (792648) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Positive 

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Web page last updated on November 24, 2008