National Toxicology Program

CASRN: 15356-70-4

Formula: C10 H20 O

Synonyms/Common Names:

• CYCLOHEXANOL, 5-METHYL-2-(1-METHYLETHYL)-(1ALPHA,2BETA,5ALPHA)- (9CI)

Known Uses:

USED FOR COOLING EFFECTS, MINT FLAVOR AND ODOR, IN CIGARETTES, OVER THE COUNTER DRUGS, COSMETICS, FOOD AND BEVERAGES.

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C50000) Completed 
  • NTIS No. PB288761  (Peer Review 08/31/1978)
    Citation: Bioassay of dl-Menthol for Possible Carcinogenicity (CAS No. 89-78-1)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C50000) Completed 
  • NTIS No. PB288761  (Peer Review 08/31/1978)
    Citation: Bioassay of dl-Menthol for Possible Carcinogenicity (CAS No. 89-78-1)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,930,15000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C50000) Report Complete 
  • TR-098 (NTIS No. PB288761)  (Peer Review 08/31/1978)
    Bioassay of dl-Menthol for Possible Carcinogenicity (CAS No. 89-78-1)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,3750,7500, M: 0,2000,4000 PPM/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (097978) Completed 
  • Mice
  • Chromosome Aberation  Equivocal 
• In Vitro Cytogenetics (CA/SCE)  (423321) Completed 
  • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in Vitro IV: Results for l5 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Drosophila  (231138) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (979487) Completed 
  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
  •  Negative 
• Micronucleus  (813096) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (506811) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative 
• Sister Chromatid Exchanges  (097978) Completed 
  • Mice
  • Sister Chromatid  Negative (Nonstandard Protocol)