Testing Information

Testing Status of Agents at NTP

3-Chloromethylpyridine hydrochloride

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http://ntp.niehs.nih.gov/go/TS-10739-F

CASRN: 6959-48-4

Related: 2-CHLOROMETHYLPYRIDINE HYDROCHLORIDE (CAS 6959-47-3)

Formula: C6-H6-Cl-N.Cl-H

Known Uses:

RESEARCH CHEMICAL

Short-Term Toxicity

  • 14-Day (Gavage)  (C03838) Completed 
    • NTIS No. PB287125  (Peer Review 10/25/1978)
      Citation: Bioassay of 3-(Chloromethyl) pyridine Hydrochloride for Possible Carcinogenicity (CAS No. 6959-48-4)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C03838) Completed 
    • NTIS No. PB287125  (Peer Review 10/25/1978)
      Citation: Bioassay of 3-(Chloromethyl) pyridine Hydrochloride for Possible Carcinogenicity (CAS No. 6959-48-4)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,68,316, M: 0,100,464 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C03838) Report Complete 
    • TR-095 (NTIS No. PB287125)  (Peer Review 10/25/1978)
      Bioassay of 3-(Chloromethyl) pyridine Hydrochloride for Possible Carcinogenicity (CAS No. 6959-48-4)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Equivocal 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,75,150, M: 0,100,200 MG/KG/50 PER GROUP

Genetic Toxicology

  • Chromosome Aberrations  (562806) Completed 
    • Mice
    • Chromosome Aberation  Negative (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (240038) Completed 
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Drosophila  (661875) Completed 
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Drosophila  (805997) Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma (NCI)  (G05039) Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mouse Lymphoma-NCI  Positive 
  • Mouse Lymphoma (NCI)  (G35871) Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mouse Lymphoma-NCI  Positive 
  • Mouse Lymphoma  (579799) Completed 
    • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
    •  Positive 
  • Micronucleus  (A85363) Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella (NCI)  (N-9240) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella-NCI  Positive 
  • Salmonella  (490641) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Positive 
  • Sister Chromatid Exchanges  (562806) Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 

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Web page last updated on November 24, 2008