National Toxicology Program

CASRN: 3567-69-9

Formula: C20-H14-N2-O7-S2.2NA

Synonyms/Common Names:

• 4-HYDROXY-3-((4-SULFO-1-NAPHTHALENYL)AZO)-1-NAPHTHALENESULFONIC ACID DISODIUMS SALT (9CI)
• RED 14, C.I. ACID

Known Uses:

DYE FOR NYLON, SILK, WOOL, LEATHER, PAPER, WOOD

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C53849) Completed 
  • NTIS No. PB82-201468  (Peer Review 10/15/1980)
    Citation: Carcinogenesis Bioassay of C.I. Acid Red 14 (CAS No. 3567-69-9) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C53849) Completed 
  • NTIS No. PB82-201468  (Peer Review 10/15/1980)
    Citation: Carcinogenesis Bioassay of C.I. Acid Red 14 (CAS No. 3567-69-9) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,6000,100000 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C53849) Report Complete 
  • TR-220 (NTIS No. PB82-201468)  (Peer Review 10/15/1980)
    Carcinogenesis Bioassay of C.I. Acid Red 14 (CAS No. 3567-69-9) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: MR: 0,6000,12500, FR: 0,12500,25000, M: 0,3000,6000 PPM/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (142045) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (831530) Completed 
  • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Inconclusive 
• Drosophila  (972991) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (561870) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Negative 
• Micronucleus  (869362) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (045886) On Test 
• Salmonella  (584000) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Sister Chromatid Exchanges  (142045) Completed 
  • Mice
  • Sister Chromatid  Positive