National Toxicology Program

CASRN: 2698-41-1

Related: CHLOROBENZALMALONONITRILE (CAS 35254-70-7)

Formula: C10-H5-CL-N2

Synonyms/Common Names:

• 2-CHLOROBENZALONONITRILE
• CS
• MALONONITRILE, O-CHLOROBENZYLIDENE-
• PROPANEDINITRILE ((2-CHLOROPENYL)METHYLENE)- (9CI)

Known Uses:

RIOT CONTROL AGENT. (TDB)

Short-Term Toxicity

• 14-Day (Inhalation)  (C55118) Completed 
  • NTIS No. PB90-256280  (Peer Review 11/20/1989)
    Citation: Toxicology and Carcinogenesis Studies of CS2 (94 o-Chlorobenzalmalononitrile, CAS No. 2698-41-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Inhalation)  (C55118) Completed 
  • NTIS No. PB90-256280  (Peer Review 11/20/1989)
    Citation: Toxicology and Carcinogenesis Studies of CS2 (94 o-Chlorobenzalmalononitrile, CAS No. 2698-41-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,.4,6.0 MG/M3/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C55118) Report Complete 
  • TR-377 (NTIS No. PB90-256280)  (Peer Review 11/20/1989)
    Toxicology and Carcinogenesis Studies of CS2 (94 o-Chlorobenzalmalononitrile, CAS No. 2698-41-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0,.075,.25,.75, M: 0,.75,1.5 MG/M3/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (171099) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (668414) Completed 
  • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
  •  Positive 
• Salmonella  (704784) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Inconclusive 
• Salmonella  (825580) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Inconclusive