Testing Information

Testing Status of Agents at NTP

2,3,5,6-Tetrachloro-4-nitroanisole

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CASRN: 2438-88-2

Formula: C7 H3 CL4 N O3

Synonyms/Common Names:

  • 1,2,4,5-TETRACHLORO-3-METHOXY-6-NITRO- (9CI)

Known Uses:

FUNGICIDE; ACARICIDE

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03032) Completed 
    • NTIS No. PB287642  (Peer Review 06/29/1978)
      Citation: Bioassay of 2,3,5,6-Tetrachloro-4-nitroanisole for Possible Carcinogenicity (CAS No. 2438-88-2)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03032) Completed 
    • NTIS No. PB287642  (Peer Review 06/29/1978)
      Citation: Bioassay of 2,3,5,6-Tetrachloro-4-nitroanisole for Possible Carcinogenicity (CAS No. 2438-88-2)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,.003,.4 %/10 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03032) Report Complete 
    • TR-114 (NTIS No. PB287642)  (Peer Review 06/29/1978)
      Bioassay of 2,3,5,6-Tetrachloro-4-nitroanisole for Possible Carcinogenicity (CAS No. 2438-88-2)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0,.006,.012 %/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (997382) Completed 
    • Chromosome Aberation Inconclusive 
    • Sister Chromatid Exchange Positive 
  • Mouse Lymphoma  (665415) Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    •  Positive 
  • Salmonella (NCI)  (N-9347) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella-NCI  Positive 
    • Salmonella-NCI  Negative 
  • Salmonella  (966907) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Negative 

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Web page last updated on November 24, 2008