Testing Information

Testing Status of Agents at NTP

C.I. Direct blue 15

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http://ntp.niehs.nih.gov/go/TS-10701-A

CASRN: 2429-74-5

Formula: C34-H28-N6-O16-S4.4Na

Synonyms/Common Names:

  • BLUE 15, C.I. DIRECT
  • 3,3'-((3,3'-DIMETHOXY(1,1'-BIPHENYL)-4,4'-DIYL)BIS(AZO))BIS(5-AMINO-4-HYDROXY)-2,7-NAPTHALENE DISULFONIC ACID TETRASODIUM SALT (9CI)

Known Uses:

DYE FOR SILK, WOOL, VISCOSE, LEATHER, PAPER, CELLULOSE FIBERS. BIOLOGICAL STAIN. TINT FOR CINEMATOGRAPHIC FILMS. (TDB)

Short-Term Toxicity

  • 14-Day (Dosed-Water)  (C61290) Completed 
    • NTIS No. PB93-126373  (Peer Review 11/19/1990)
      Citation: Toxicology and Carcinogenesis Studies of C.I. Direct Blue 15 (CAS No. 2429-74-5) in F344 Rats (Drinking Water Studies)
    • Rats: F344/N
  • 13-Week (Dosed-Water)  (C61290) Completed 
    • NTIS No. PB93-126373  (Peer Review 11/19/1990)
      Citation: Toxicology and Carcinogenesis Studies of C.I. Direct Blue 15 (CAS No. 2429-74-5) in F344 Rats (Drinking Water Studies)
    • Rats: F344/N
    • Dose: MR: 0, 1250, 2500, 5000, 10000, 30000 PPM (10 PER GROUP) FR: 0, 630, 1250, 2500, 5000, 10000 PPM (10 PER GROUP)

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Water)  (C61290) Report Complete 
    • TR-397 (NTIS No. PB93-126373)  (Peer Review 11/19/1990)
      Toxicology and Carcinogenesis Studies of C.I. Direct Blue 15 (CAS No. 2429-74-5) in F344 Rats (Drinking Water Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
    • Dose: RATS ONLY: 0,630,1250,2500 PPM (70,45,75,70 PER GROUP RESPECTIVELY)

Special Studies

  • Metabolism (Gavage)  (S0018) Completed 
    • Citation: LYNN, RK, DONIELSON, DW, ILIAS, AM, KENNISH, JM, WONG,K & MATTHEWS, HB: METABOLISM OF BISAZOBIPHENYL DYES DERIVED FROM BENZIDINE, 3,3'-DIMETHYLBENZIDINE OR 3,3'-DIMETHOXYBENZIDINE TO CARCINOGENIC AROMATIC AMINES IN THE DOG & RAT. TOXICOL APPL PHARMACOL, 56:248-258,1980.
    • F Dog; M Rats: Sprague Dawley
    • Dose: DOGS: 100 MG/KG; RATS 100 MG/KG

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (279945) Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • Salmonella  (191506) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella Reduction  (439816) Completed 
    • Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
    •  Positive 

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Web page last updated on November 24, 2008