National Toxicology Program

CASRN: 2243-62-1

Formula: C10 H10 N2

Synonyms/Common Names:

• 1,5-DIAMINONAPHTHALENE (9CI)

Known Uses:

DYE AND DRUG INTERMEDIATE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03021) Completed 
  • NTIS No. PB287646  (Peer Review 06/29/1978)
    Citation: Bioassay of 1,5-Naphthalenediamine for Possible Carcinogenicity (CAS No. 2243-62-1)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03021) Completed 
  • NTIS No. PB287646  (Peer Review 06/29/1978)
    Citation: Bioassay of 1,5-Naphthalenediamine for Possible Carcinogenicity (CAS No. 2243-62-1)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,.03,3.0 %/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03021) Report Complete 
  • TR-143 (NTIS No. PB287646)  (Peer Review 06/29/1978)
    Bioassay of 1,5-Naphthalenediamine for Possible Carcinogenicity (CAS No. 2243-62-1)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Positive 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: R: 0,.05,1.0, M: 0,.1,.2 %/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (531218) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Salmonella (NCI)  (N-9347) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive 
  • Salmonella-NCI  Negative 
• Salmonella  (279457) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Positive