National Toxicology Program

CASRN: 2164-17-2

Formula: C10 H11 F3 N2 O

Synonyms/Common Names:

• N,N-DIMETHYL-N'-(3-(TRIFLUOROMETHYL)PHENYL)-UREA (9CI)

Known Uses:

PHENYLUREA HERBICIDE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C08695) Completed 
  • NTIS No. PB80-217904  (Peer Review 02/15/1980)
    Citation: Bioassay of Fluometuron for Possible Carcinogenicity (CAS No. 2164-17-2)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C08695) Completed 
  • NTIS No. PB80-217904  (Peer Review 02/15/1980)
    Citation: Bioassay of Fluometuron for Possible Carcinogenicity (CAS No. 2164-17-2)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,250,4000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C08695) Report Complete 
  • TR-195 (NTIS No. PB80-217904)  (Peer Review 02/15/1980)
    Bioassay of Fluometuron for Possible Carcinogenicity (CAS No. 2164-17-2)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Equivocal 
  • Female Mice Negative 
  • Dose: R: 0,125,250, M: 0,500,1000 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (054432) Completed 
  • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (134145) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Negative 
• Salmonella (NCI)  (N-9315) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Negative 
• Salmonella  (335349) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Negative