National Toxicology Program

CASRN: 26471-62-5

Formula: C9 H6 N2 O2

Synonyms/Common Names:

• 1,3-DIISOCYANATOMETHYL BENZENE (9CI)
• ISOCYANIC ACID, METHYL-M-PHENYLENE ESTER
• TDI

Known Uses:

MANUFACTURE OF FLEXIBLE POLYURETHANE FOAMS AND COATINGS FOR LACQUER AND WOOD FINISHES

Short-Term Toxicity

• 14-Day (Gavage)  (C50533) Completed 
  • NTIS No. PB87-115176  (Peer Review 09/22/1982)
    Citation: Toxicology and Carcinogenesis Studies of Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate (CAS No. 26471-62-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C50533) Completed 
  • NTIS No. PB87-115176  (Peer Review 09/22/1982)
    Citation: Toxicology and Carcinogenesis Studies of Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate (CAS No. 26471-62-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,.15,240 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C50533) Report Complete 
  • TR-251 (NTIS No. PB87-115176)  (Peer Review 09/22/1982)
    Toxicology and Carcinogenesis Studies of Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate (CAS No. 26471-62-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Negative 
  • Female Mice Positive 
  • Dose: MR: 0,30,60, FR&FM: 0,60,120, MM: 0,120,240, MG/KG/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage)  (S0057) Completed 
  • M Rats: F344
  • Dose: 60, 900 MG/KG
• Metabolism (Gavage)  (S0745) Completed 
  • Citation: DIETER, M.P., BOORMAN, G.A., JAMESON, C.W., MATTHEWS, H.B., & HUFF, J.E., THE CARCINOGENIC ACTIVITY OF COMMERCIAL GRADE TOLUENE DIISOCYANATE IN RATS AND MICE IN RELATION TO THE METABOLISM OF THE 2,4- AND 2,6-TDI ISOMERS
  • M Rats: F344; M/F Mice: B6C3F1
  • Dose: Females: 60 or 120 mg/kg, Male rats 30 or 60 mg/kg, Male mice: 120 or 240 mg/kg

Genetic Toxicology

• Chromosome Aberrations  (544551) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (161856) Completed 
  • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Weakly Positive 
• Drosophila  (892839) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Positive 
• Salmonella  (654636) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Positive 
• Sister Chromatid Exchanges  (544551) Completed 
  • Mice
  • Sister Chromatid  Positive (Nonstandard Protocol)