Testing Status of Agents at NTP
3-Nitropropionic acid
CASRN: 504-88-1
Formula: C3-H5-N-O4
Synonyms/Common Names:
- BETA-NITROPROPANOIC ACID
Known Uses:
NATURALLY OCCURRING; FOOD CONTAMINANT
Short-Term Toxicity
- 13-WEEK (Gavage)
(C03076) Completed
- NTIS No. PB281102
(Peer Review 01/18/1978)
Citation: Bioassay of 3-Nitropropionic Acid for Possible Carcinogenicity (CAS No. 504-88-1) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,100,900, M: 0,150,800 MG/10 PER GROUP
- NTIS No. PB281102
(Peer Review 01/18/1978)
Long-Term Carcinogenicity
- 2-YEAR (Gavage)
(C03076) Report Complete
- TR-052 (NTIS No. PB281102)
(Peer Review 01/18/1978)
Bioassay of 3-Nitropropionic Acid for Possible Carcinogenicity (CAS No. 504-88-1) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: MR: 0,.425,.85, FR: 0,.6,1.2, M: 0,.375,.75 MG/50 PER GROUP
- TR-052 (NTIS No. PB281102)
(Peer Review 01/18/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(892866) Completed
- Chromosome Aberation Weakly Positive
- Sister Chromatid Exchange Positive
- Mouse Lymphoma (NCI)
(G46070) Completed
- Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
- Mouse Lymphoma-NCI Positive
- Mouse Lymphoma (NCI)
(G63977) Completed
- Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
- Mouse Lymphoma-NCI Positive
- Salmonella (NCI)
(N-9198) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Positive
- Salmonella
(290153) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Positive
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