National Toxicology Program

CASRN: 434-13-9

Formula: C24 H40 O3

Synonyms/Common Names:

• (3ALPHA,5BETA)-3-HYDROXY-CHOLAN-24-OIC ACID (9CI)

Known Uses:

BIOLOGICAL RESEARCH CHEMICAL FOUND IN HUMAN & OX BILE (MERCK 1989)

Short-Term Toxicity

• 14-Day (Gavage)  (C03861) Completed 
  • NTIS No. PB288476  (Peer Review 08/31/1978)
    Citation: Bioassay of Lithocholic Acid for Possible Carcinogenicity (CAS No. 434-13-9)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C03861) Completed 
  • NTIS No. PB288476  (Peer Review 08/31/1978)
    Citation: Bioassay of Lithocholic Acid for Possible Carcinogenicity (CAS No. 434-13-9)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,464,2150 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C03861) Report Complete 
  • TR-175 (NTIS No. PB288476)  (Peer Review 08/31/1978)
    Bioassay of Lithocholic Acid for Possible Carcinogenicity (CAS No. 434-13-9)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,250,500, M: 0,125,250 MG/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (963393) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma (NCI)  (G56739) Completed 
  • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
  • Mouse Lymphoma-NCI  Positive 
• Mouse Lymphoma (NCI)  (G78265) Completed 
  • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
  • Mouse Lymphoma-NCI  Negative 
• Mouse Lymphoma  (244935) Completed 
  • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
  •  Positive 
• Salmonella (NCI)  (N-9253) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Negative 
• Salmonella  (486118) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Negative