National Toxicology Program

CASRN: 134-29-2

Related: O-ANISIDINE (90-04-0)

Formula: C7 H9 N O.CL H

Synonyms/Common Names:

• 2-METHOXYBENZENAMINE HYDROCHLORIDE (9CI)

Known Uses:

MANUFACTURE OF AZO DYES; FORMERLY LISTED AS POSSIBLE INGREDIENT IN PERMANENT OXIDATION HAIR DYES (NO LONGER USED IN THE US)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03747) Completed 
  • NTIS No. PB285879  (Peer Review 04/26/1978)
    Citation: Bioassay of o-Anisidine Hydrochloride for Possible Carcinogenicity (CAS No. 134-29-2)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03747) Completed 
  • NTIS No. PB285879  (Peer Review 04/26/1978)
    Citation: Bioassay of o-Anisidine Hydrochloride for Possible Carcinogenicity (CAS No. 134-29-2)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,1000,30000 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03747) Report Complete 
  • TR-089 (NTIS No. PB285879)  (Peer Review 04/26/1978)
    Bioassay of o-Anisidine Hydrochloride for Possible Carcinogenicity (CAS No. 134-29-2)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: R: 0,5000,10000, M: 0,2500,5000 PPM/55 PER GROUP

Genetic Toxicology

• Micronucleus  (563139) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella (NCI)  (N-9366) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive