Testing Information

Testing Status of Agents at NTP

tris(2,3-Dibromopropyl) phosphate

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http://ntp.niehs.nih.gov/go/TS-10571-V

CASRN: 126-72-7

Formula: C9 H15 BR6 O4 P

Synonyms/Common Names:

  • 2,3-DIBROMO-1-PROPANOL PHOSPHATE (3:1) (9CI)
  • TRIS(DIBROMOPROPYL)PHOSPHATE

Known Uses:

FLAME RETARDANT

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03270) Completed 
    • NTIS No. PB280271  (Peer Review 03/06/1978)
      Citation: Bioassay of Tris (2,3-Dibromopropyl) Phosphate for Possible Carcinogenicity (CAS No. 126-72-7)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03270) Completed 
    • NTIS No. PB280271  (Peer Review 03/06/1978)
      Citation: Bioassay of Tris (2,3-Dibromopropyl) Phosphate for Possible Carcinogenicity (CAS No. 126-72-7)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,1,100, M: 0,10,1000 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03270) Report Complete 
    • TR-076 (NTIS No. PB280271)  (Peer Review 03/06/1978)
      Bioassay of Tris (2,3-Dibromopropyl) Phosphate for Possible Carcinogenicity (CAS No. 126-72-7)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,50,100, M: 0,500,1000 PPM/55 PER GROUP

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0006) Completed 
    • Citation: NOMEIR, A.A. & MATTHEWS, H.B.: METABOLISM & DISPOSITION OF THE FLAME RETARDANT TRIS(2,3-DIBROMOPROPYL)PHOSPHATE IN THE RAT, TOXICOL & APPL PHARM, 67:357-369, 1983.
    • M Rats: F344
    • Dose: PO/IV: 1.39 MG/KG
  • Absorption Disposition Metabolism Elimination (Intravenous)  (S0036) Completed 
    • Citation: LYNN ET AL. METABOLISM, DISTRIBUTION, & EXCRETION OF THE FLAME RETARDANT, TRIS(2,3-DIBROMOPROPYL) PHOSPHATE (TRIS-BP) IN THE RAT: IDENTIFICATION OF MUTAGENIC & NEPHROTOXIC METABOLITES. TOXICOLOGY & APPLIED PHARMACOLOGY 63, 105-119 (1982). LYNN. PHARMACOKINETICS OF XENOBIOTICS. FINAL REPORT: TRIS(2,3-DIBROMOPROPYL) PHOSPHATE (TRIS-BP): BACTERIAL MUTAGENICITY & NEPHROTOXICITY STUDIES. OHSU. FEB 1982
    • M Rats: F344
  • Cell Proliferation (Dosed-Feed)  (S0147) Completed 
    • Citation: CUNNINGHAM, ML, ELWELL, MR, & MATTHEWS, HB; SITE-SPECIFIC CELL PROLIFERATION IN RENAL TUBULAR CELLS BY THE RENAL TUBULAR CARCINOGEN TRIS (2,3-)DIBROMOPROPYL)PHOSPHATE, EHP 101(SUPPL 5):253-258, 1993.
    • M Rats: F344
    • Dose: 50, 100 PPM
  • Cell Proliferation  (S0672) Completed 
    • Citation: RELATIONSHIP OF CARCINOGENICITY AND CELLULAR PROLILFERATIONS INDUCED BY MUTAGENIC NONCARCINOGENS VS CARCINOGENS M.L. CUNNINGHAM, M. R. ELWELL, H. B. MATTHEWS FUNDAMENTAL AND APPLIED TOXICOLOGY 23, 363-369 (1994)
    • M Rats: F344
  • Mechanisms (Intravenous)  (S0442) Completed 
    • Citation: MORALES, N.M. & MATTHEWS, H.B., IN VIVO BINDING OF THE FLAME RETARDANTS TRIS(2,3-DIBROMOPROPYL) PHOSPHATE & TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE TO MACROMOLECULES OF MOUSE LIVER, KIDNEY & MUSCLE, BULL ENVIRONM CONTAM TOXICOL 25:34-38, 1980.
    • M Mice

Genetic Toxicology

  • Salmonella (NCI)  (N-9383) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella-NCI  Positive 

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Web page last updated on November 24, 2008