National Toxicology Program

CASRN: 123-91-1

Related: 1,3-DIOXANE (CAS 505-22-6)

Formula: C4-H8-O2

Synonyms/Common Names:

• P-DIOXANE

Known Uses:

INDUSTRIAL AND LAB SOLVENT USED IN LACQUERS, PAINTS, DYES, RESINS, OILS AND WAXES.

Short-Term Toxicity

• 13-WEEK (Dosed-Water)  (C03689B) Completed 
  • NTIS No. PB285711  (Peer Review 03/07/1978)
    Citation: Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CAS No. 123-91-1)
  • Rats: Osborne Mendel; Mice: B6C3F1

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Water)  (C03689B) Report Complete 
  • TR-080 (NTIS No. PB285711)  (Peer Review 03/07/1978)
    Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CAS No. 123-91-1)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: 0,0.5,1.0 %/70R - 100M PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (950869) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Weakly Positive 
• Drosophila  (058941) Completed 
  • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (120802) Completed 
  • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
  •  Negative 
• Micronucleus  (787385) Completed 
  • Mice: B6C3F1
  • Male Equivocal 
• Micronucleus  (906732) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (123659) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Salmonella  (709799) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Salmonella  (882515) Completed 
  •  Negative