National Toxicology Program

CASRN: 121-79-9

Formula: C10-H12-O5

Synonyms/Common Names:

• 3,4,5-TRIHYDROXYBENZOIC ACID PROPYLESTER (9CI)

Known Uses:

ANTIOXIDANT IN FOODS CONTAINING FATS/OILS, FOOD PACKAGING MATERIALS, AND COSMETICS

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C50588) Completed 
  • NTIS No. PB83-180042  (Peer Review 12/16/1981)
    Citation: Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C50588) Completed 
  • NTIS No. PB83-180042  (Peer Review 12/16/1981)
    Citation: Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,1500,25000, M: 0,800,12500 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C50588) Report Complete 
  • TR-240 (NTIS No. PB83-180042)  (Peer Review 12/16/1981)
    Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal 
  • Female Rats Negative 
  • Male Mice Equivocal 
  • Female Mice Negative 
  • Dose: 0,6000,12000 PPM/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (299865) Completed 
  • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
  • Mice
  • Chromosome Aberation  Positive 
• In Vitro Cytogenetics (CA/SCE)  (257022) Completed 
  • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (677217) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive 
• Mouse Lymphoma  (099874) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Micronucleus  (512803) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A73992) Completed 
  • Mice: B6C3F1
  • Male Positive 
• Salmonella  (985325) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Sister Chromatid Exchanges  (299865) Completed 
  • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
  • Mice
  • Sister Chromatid  Negative (Nonstandard Protocol)