National Toxicology Program

CASRN: 121-75-5

Formula: C10-H19-O6-P-S2

Synonyms/Common Names:

• ((DIMETHOXYPHOSPHINOTHIOYL)THIO)-BUTANEDIOIC ACID (9CI)

Known Uses:

INSECTICIDE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00215B) Completed 
  • NTIS No. PB300301  (Peer Review 05/01/1979)
    Citation: Bioassay of Malathion for Possible Carcinogenicity (CAS No. 121-75-5)
  • Rats: F344/N
• 13-WEEK (Dosed-Feed)  (C00215A) Completed 
  • NTIS No. PB278527  (Peer Review 01/18/1978)
    Citation: Bioassay of Malathion for Possible Carcinogenicity (CAS No. 121-75-5)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,8000,32000, M: 0,4000,32000 PPM/10 PER GROUP
• 13-Week (Dosed-Feed)  (C00215B) Completed 
  • NTIS No. PB300301  (Peer Review 05/01/1979)
    Citation: Bioassay of Malathion for Possible Carcinogenicity (CAS No. 121-75-5)
  • Rats: F344/N
  • Dose: 0,1000,16000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C00215A) Report Complete 
  • TR-024 (NTIS No. PB278527)  (Peer Review 01/18/1978)
    Bioassay of Malathion for Possible Carcinogenicity (CAS No. 121-75-5)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,6000,10000 (AVG), M: 0,8000,16000 (AVG) PPM/50 PER GROUP
• 2-Year (Dosed-Feed)  (C00215B) Report Complete 
  • TR-192 (NTIS No. PB300301)  (Peer Review 05/01/1979)
    Bioassay of Malathion for Possible Carcinogenicity (CAS No. 121-75-5)
  • Rats: F344/N
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Dose: 0,2000,4000 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (973704) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (911111) Completed 
  •  Inconclusive 
• Salmonella  (218242) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative