National Toxicology Program

CASRN: 120-61-6

Formula: C10-H10-O4

Synonyms/Common Names:

• 1,4-BENZENEDICARBOXYLIC ACID DIMETHYL ESTER (9CI)

Known Uses:

SYNTHESIS OF POLYESTER FIBER

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C50055) Completed 
  • NTIS No. PB299903  (Peer Review 12/13/1978)
    Citation: Bioassay of Dimethyl Terephthalate for Possible Carcinogenicity (CAS No. 120-61-6)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C50055) Completed 
  • NTIS No. PB299903  (Peer Review 12/13/1978)
    Citation: Bioassay of Dimethyl Terephthalate for Possible Carcinogenicity (CAS No. 120-61-6)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,1750,20000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C50055) Report Complete 
  • TR-121 (NTIS No. PB299903)  (Peer Review 12/13/1978)
    Bioassay of Dimethyl Terephthalate for Possible Carcinogenicity (CAS No. 120-61-6)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Equivocal 
  • Female Mice Negative 
  • Dose: 0,2500,5000 PPM/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (454441) Completed 
  • Mice
  • Chromosome Aberation  Equivocal 
• In Vitro Cytogenetics (CA/SCE)  (822999) Completed 
  • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Drosophila  (551959) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (954536) Completed 
  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
  •  Negative 
• Micronucleus  (184029) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (003881) Completed 
  • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
  •  Negative 
• Sister Chromatid Exchanges  (454441) Completed 
  • Mice
  • Sister Chromatid  Equivocal