National Toxicology Program

CASRN: 111-42-2

Formula: C4-H11-N-O2

Synonyms/Common Names:

• DEA
• 2,2'-IMINOBISETHANOL

Known Uses:

IN PRODUCTION OF TEXTILE LUBRICANTS. RUBBER CHEMICALS INTERMEDIATE. EMULSIFIER IN AGRICULTURAL CHEMICALS, COSMETICS, AND PHARMACEUTICALS. GAS CONDITIONING AGENT. (TDB)

Short-Term Toxicity

• 2-WEEK (Topical Application)  (C55174B) Completed 
  • TOX-20 (NTIS No. PB93-133999)  (Peer Review 11/21/1991)
    Toxicity Studies of Diethanolamine (CAS No. 111-42-2) Administered Topically and in Drinking Water to F344/N Rats and B6C3F1Mice
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 125, 250, 500, 1000, AND 2000 MG/KG; M: 0, 160, 320, 630, 1250, and 2500 mg/kg/ 5D/WK
• 2-WEEK (Dosed-Water)  (C55174C) Completed 
  • TOX-20 (NTIS No. PB93-133999)  (Peer Review 11/21/1991)
    Toxicity Studies of Diethanolamine (CAS No. 111-42-2) Administered Topically and in Drinking Water to F344/N Rats and B6C3F1Mice
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 630, 1250, 2500, 5000, 10000 PPM
• 13-WEEK (Topical Application)  (C55174B) Report Complete 
  • TOX-20 (NTIS No. PB93-133999)  (Peer Review 11/21/1991)
    Toxicity Studies of Diethanolamine (CAS No. 111-42-2) Administered Topically and in Drinking Water to F344/N Rats and B6C3F1Mice
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 32, 63, 125, 250, 500 MG/KG; M: 0, 80, 160, 320, 630, OR 1250 MG/KG
• 13-WEEK (Dosed-Water)  (C55174C) Report Complete 
  • TOX-20 (NTIS No. PB93-133999)  (Peer Review 11/21/1991)
    Toxicity Studies of Diethanolamine (CAS No. 111-42-2) Administered Topically and in Drinking Water to F344/N Rats and B6C3F1Mice
  • Rats: F344/N; Mice: B6C3F1
  • Dose: MR: 0, 320, 630, 1250, 2500, OR 5000 PPM; FR: 0, 160, 320, 630, 1250, OR 2500 PPM; M: 0, 630, 1250, 2500, 5000, OR 10000 PPM

Long-Term Carcinogenicity

• 2-YEAR (Topical Application)  (C55174D) Report Complete 
  • TR-478 (NTIS No. PB99-167553)  (Peer Review 12/10/1997)
    Toxicology and Carcinogenesis Studies of Diethanolamine (CAS No. 111-42-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: MR: 0, 16, 32, OR 64 MG/KG; FR: 0, 8, 16, OR 32 MG/KG; MICE: 0, 40, 80, OR 160 MG/KG (50/SEX/SPECIES/GROUP)

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous; Gavage; Topical Application; Intravenous; Gavage; Topical Application)  (S0145) Completed 
  • Citation: MATTHEWS, JM ET AL "METABOLISM, BIOACCULATION & INCORPORATION OF DIETHANOLAMINE INTO PHOSPHOLIPIDS" CHEMICAL RESEARCH IN TOXICOLOGY, VOL 8, NO 5, 1995 PGS 625-633
  • M Rats: F344; M Rats: F344; M Rats: F344; M Mice: B6C3F1; M Mice: B6C3F1; M Mice: B6C3F1
• Absorption Disposition Metabolism Elimination  (S0813) Completed 
  • Rats; Mice
• Absorption Disposition Metabolism Elimination  (S0814) Completed 
  • Citation: PROJECT REPORT # 1 ABSORPTION AND DISPOSITION OF DEA IN RATS AND MICE AFTER ORAL, DERMAL AND INTRAVENOUS ADMINISTRATION
  • Rats; Mice

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (095123) Completed 
  • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (375254) Completed 
  •  Negative 
• Micronucleus  (A08796) Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (310797) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 

Organ Systems Toxicity

• 14 DAYS Immunotoxicity (Gavage)  (IMM20004) Completed 
  • F Mice: B6C3F1
  • Dose: 0, 100, 300, 400, 500, 600, 700, 800, 900, 1000, 1250, OR 1500 MG/KG
• 14 DAYS Immunotoxicity (Gavage)  (IMM20303) Completed 
  • F Rats: F344/N
  • Dose: 0, 50 100, OR 200 MG/KG
• 14 DAYS Immunotoxicity (Gavage)  (IMM98011) Completed 
  • F Mice: B6C3F1
  • Dose: 0, 100, 300, OR 600 MG/KG (STUDIES 1-11 AND 13); 0, 300, 600, OR 800 MG/KG (STUDY 12)
• 30 DAYS Neurotoxicology Assessment (Gavage)  (NTA20101) Completed 
  • M/F Rats: Sprague Dawley
  • Dose: 0, 6.67, 20, OR 60 MG/KG
• GD 6-15 (COPULATORY PLUG = GD 0) Short-Term in vivo Repro. Tox. (Gavage)  (T0074) Completed 
  • F Mice: Swiss
• GD 6 TO 19 Conventional Teratology (Gavage)  (TER96001) Completed 
  • NTIS No. PB2001-103718
    Citation: Developmental Toxicity Screen for Diethanolamine (CAS No. 111-42-2) Administered by Gavage to Sprague-Dawley (CD®) Rats on Gestational Days 6 through 19: Evaluation of Dams and Pups through Postnatal Day 21
  • F Rats: Sprague Dawley
  • Dose: 0, 50, 125, 200, 250, OR 300 MG/KG/DAY
• GD 6 THROUGH 15 Teratology Pilot Studies (Gavage)  (TRP90012) Completed 
  • F Rats: Sprague Dawley
  • Dose: 0, 50, 200, 500, 800, OR 1200 MG/KG