National Toxicology Program

CASRN: 107-05-1

Formula: C3 H5 CL

Synonyms/Common Names:

• 3-CHLORO-1-PROPENE

Known Uses:

PREPARATION OF GLYCEROL, EPICHLOROHYDRIN, PHARMACEUTICALS, INSECTICIDES, RESINS FOR VARNISHES, PLASTICS, ADHESIVES

Short-Term Toxicity

• 14-Day (Gavage)  (C04615) Completed 
  • NTIS No. PB287516  (Peer Review 06/29/1978)
    Citation: Bioassay of Allyl Chloride for Possible Carcinogenicity (CAS No. 107-05-1)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Gavage)  (C04615) Completed 
  • NTIS No. PB287516  (Peer Review 06/29/1978)
    Citation: Bioassay of Allyl Chloride for Possible Carcinogenicity (CAS No. 107-05-1)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,56,562, M: 0,178,1780 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C04615) Report Complete 
  • TR-073 (NTIS No. PB287516)  (Peer Review 06/29/1978)
    Bioassay of Allyl Chloride for Possible Carcinogenicity (CAS No. 107-05-1)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Equivocal 
  • Female Mice Equivocal 
  • Dose: FR: 0,55,73 (AVG), MR: 0,57,77 (AVG), FM: 0,129,258 (AVG), MM: 0,172,199 (AVG) MG/KG/50 PER GROUP

Genetic Toxicology

• Salmonella  (096311) Completed 
  • Citation: McGregor, D.B., Reynolds, D.M., and Zeiger, E. Conditions affecting the mutagenicity of trichloroethylene in Salmonella Environ. Molec. Mutagen. Vol. 13 (1989) 197-202
  •  Positive 

Organ Systems Toxicity

• GD 7-14 Short-Term in vivo Repro. Tox. (Gavage)  (T0057) Completed 
  • NTIS No. PB83-257600
    Citation: Screening of Priority Chemicals for Reproductive Hazards
  • F Mice: Swiss
  • Dose: 500 MG/KG BODY WEIGHT