Testing Information

Testing Status of Agents at NTP

p-Benzoquinone dioxime

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http://ntp.niehs.nih.gov/go/TS-10502-T

CASRN: 105-11-3

Related: P-BENZOQUINONE MONOOXIME (CAS 637-62-7)

Formula: C6-H6-N2-O2

Synonyms/Common Names:

  • 2,5-CYCLOHEXADIENE-1,4-DIONE, DIOXIME (9CI)
  • P-QUINONE DIOXIME

Known Uses:

VULCANIZATION OF RUBBER

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03850) Completed 
    • NTIS No. PB291501  (Peer Review 10/25/1978)
      Citation: Bioassay of p-Quinone Dioxime for Possible Carcinogenicity (CAS No. 105-11-3)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03850) Completed 
    • NTIS No. PB291501  (Peer Review 10/25/1978)
      Citation: Bioassay of p-Quinone Dioxime for Possible Carcinogenicity (CAS No. 105-11-3)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,680,10000, M: 0,680,14700 PPM/10 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03850) Report Complete 
    • TR-179 (NTIS No. PB291501)  (Peer Review 10/25/1978)
      Bioassay of p-Quinone Dioxime for Possible Carcinogenicity (CAS No. 105-11-3)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,375,750, M: 0,750,1500 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (233313) Completed 
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Drosophila  (922553) Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (034164) Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    •  Positive 
  • Salmonella (NCI)  (N-9297) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella-NCI  Positive 
  • Salmonella  (604471) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Positive 
  • Salmonella  (960242) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Positive 

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Web page last updated on November 24, 2008