National Toxicology Program

CASRN: 102-71-6

Formula: C6-H15-N-O3

Synonyms/Common Names:

• 2,2',2''-NITRILOTRIETHANOL

Known Uses:

INTERMEDIATE IN MANUF. SURFACTANTS, TEXTILE SPECIALTIES, WAXES, POLISHES, HERBICIDES, PETROLEUM DEMULSIFIERS,TOILET GOODS, CEMENT ADDITIVES, CUTTING OILS, IN MAKING MINERAL & VEG. OIL EMULSIONS, SOLVENT, PHARMACEUTIC AID (ALKALIZER) (MERCK 1989).

Short-Term Toxicity

• 14-Day (Dosed-Water)  (C61621A) Completed 
  • Rats: F344/N; Mice: B6C3F1
• 2-WEEK (Topical Application)  (C61621B) Completed 
  • Rats: F344/N; Mice: B6C3F1
• 14-Day (Inhalation)  (C61621C) Completed 
  • Rats: F344/N; Mice: B6C3F1
• 3-WEEK (Topical Application)  (C61621D) Completed 
  • NTIS No. PB2000-102846  (Peer Review 10/30/1998)
    Citation: Toxicology and Carcinogenesis Studies of Triethanolamine (CAS No. 102-71-6) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1; Mice: Sencar
• 13-WEEK (Topical Application)  (C61621B) Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,0.125,0.25,0.5,1,2 G/KG M: 0.25,0.5,1,2,4 G/KG

Long-Term Carcinogenicity

• 2-YEAR (Topical Application)  (C61621D) Report Complete 
  • TR-449 (NTIS No. PB2000-102846)  (Peer Review 10/30/1998)
    Toxicology and Carcinogenesis Studies of Triethanolamine (CAS No. 102-71-6) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal Evidence 
  • Female Rats No Evidence 
  • Male Mice Inadequate Study 
  • Female Mice Inadequate Study 
  • Dose: MR: 0, 32, 63, OR 125; FR: 0, 63, 125, OR 250; MM: 0, 200, 630, OR 2000; FM: 0, 100, 300, OR 1000 MG/KG; 60/GROUP
• 2-YEAR (Topical Application)  (C61621E) Report Complete 
  • TR-518 (NTIS No. PB2004-106613)  (Peer Review 05/22/2003)
    Toxicology and Carcinogenesis Studies of Triethanolamine (CAS No. 102-71-6) in B6C3F1 Mice (Dermal Studies)
  • Mice: B6C3F1
  • Carcinogenesis Results
  • Male Mice Equivocal Evidence 
  • Female Mice Some Evidence 
  • Dose: MM: 0, 200, 630, OR 2000 MG/KG; FM: 0, 100, 300, OR 1000 MG/KG

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous; Topical Application)  (S0652) Completed 
  • F Rats: F344; F Mice: B6C3F1; F Rats: F344; F Mice: B6C3F1
  • Dose: IV: 3 mg/kg in rats and mice; dermal: rats: 68-276 mg/kg on a 12 cm2 dose site, mice: 79-1120 mg/kg on a 1.44 com2

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (932037) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Drosophila  (771013) Completed 
  • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Micronucleus  (A38253) Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (683120) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 

Organ Systems Toxicity

• Immunotoxicity (Topical Application)  (IMM90005) Completed 
  • NTIS No. PB92-140383
    Citation: Summary Reports on Immunotoxicology Vol. 1, No. 1-15
  • Citation: SUMMARY (1-15)
  • F Mice: B6C3F1
  • Dose: 0, 3, 10, 30%
• 10 WEEKS (MATING TRIAL STUDY - RATS WERE BRED FOR A MAXIMUM OF 10 DAYS STARTING AT THE BEGINNING OF THE ELEVENTH WEEK OF DOSING -- APRIL 6 - APRIL 15, 1988) Continuous Breeding (Topical Application)  (RACB89001) Completed 
  • M/F Rats: F344/N
  • Dose: 0, 0.125, 0.25, OR 0.5 G/KG
• 10 WEEKS (MATING TRIAL STUDY - MICE WERE BRED FOR A MAXIMUM OF 10 DAYS STARTING AT THE BEGINNING OF THE ELEVENTH WEEK OF DOSING -- FEBRUARY 22 - MARCH 2, 1988) Continuous Breeding (Topical Application)  (RACB89002) Completed 
  • M/F Mice: Swiss CD-1
  • Dose: 0, 0.5, 1.0, OR 2.0 G/KG
• GD 6-15 (COPULATORY PLUG = GD 0) Short-Term in vivo Repro. Tox. (Gavage)  (T0052) Completed 
  • F Mice: Swiss
• GD 6 THROUGH 15 Teratology Pilot Studies (Gavage)  (TRP90013) Completed 
  • F Rats: Sprague Dawley
  • Dose: 0, 100, 500, 1000, 2500, OR 5000 MG/KG