National Toxicology Program

CASRN: 95-74-9

Formula: C7-H8-CL-N

Synonyms/Common Names:

• 3-CHLORO-4-METHYL-BENZENAMINE (9CI)

Known Uses:

DYE INTERMEDIATE; AVICIDE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C02040) Completed 
  • NTIS No. PB287401  (Peer Review 06/29/1978)
    Citation: Bioassay of 3-Chloro-p-Toluidine for Possible Carcinogenicity (CAS No. 95-74-9)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C02040) Completed 
  • NTIS No. PB287401  (Peer Review 06/29/1978)
    Citation: Bioassay of 3-Chloro-p-Toluidine for Possible Carcinogenicity (CAS No. 95-74-9)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,315,6800, M: 0,810,3750 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C02040) Report Complete 
  • TR-145 (NTIS No. PB287401)  (Peer Review 06/29/1978)
    Bioassay of 3-Chloro-p-Toluidine for Possible Carcinogenicity (CAS No. 95-74-9)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,1635,3269 (AVG), FM: 0,300,600, MM: 0,600,1200 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (966841) Completed 
  • Chromosome Aberation Inconclusive 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (836474) Completed 
  •  Inconclusive 
• Salmonella  (374293) Completed 
  •  Weakly Positive 
• Salmonella  (991791) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative