National Toxicology Program

CASRN: 95-50-1

Related: 1,3-DICHLOROBENZENE (541-73-1) & 1,4-DICHLOROBENZENE (106-46-7)

Formula: C6-H4-CL2

Synonyms/Common Names:

• BENZENE, 1,2-DICHLORO- (9CI)

Known Uses:

FUMIGANT. INSECTICIDE. INDUSTRIAL SOLVENT. CHEMICAL INTERMEDIATE. DEGREASING AGENT FOR METALS. HEAT TRANSFER MEDIUM. (TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C54944A) Completed 
  • NTIS No. PB86-144888  (Peer Review 09/22/1982)
    Citation: Toxicology and Carcinogenesis Studies of 1,2-Dichlorobenzene (o-Dichlorobenzene) (CAS No. 95-50-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C54944A) Completed 
  • NTIS No. PB86-144888  (Peer Review 09/22/1982)
    Citation: Toxicology and Carcinogenesis Studies of 1,2-Dichlorobenzene (o-Dichlorobenzene) (CAS No. 95-50-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,30,500 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C54944A) Report Complete 
  • TR-255 (NTIS No. PB86-144888)  (Peer Review 09/22/1982)
    Toxicology and Carcinogenesis Studies of 1,2-Dichlorobenzene (o-Dichlorobenzene) (CAS No. 95-50-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,60,120 MG/KG/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Intraperitoneal Injection; Dosed-Water)  (S0062) Completed 
  • M Rats: F344; M Rats: F344

Genetic Toxicology

• Chromosome Aberrations  (388032) Completed 
  • Mice
  • Chromosome Aberation  Positive 
• Chromosome Aberrations  (732739) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (059536) Completed 
  • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Drosophila  (934439) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (881718) Completed 
  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
  •  Positive 
• Micronucleus  (279592) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (749046) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A44739) Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (917014) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Sister Chromatid Exchanges  (388032) Completed 
  • Mice
  • Sister Chromatid  Negative 
• Sister Chromatid Exchanges  (732739) Completed 
  • Mice
  • Sister Chromatid  Negative