Testing Information

Testing Status of Agents at NTP

1,2,3-Benzotriazole

Print this pageFriendly URL

http://ntp.niehs.nih.gov/go/TS-10453-G

CASRN: 95-14-7

Formula: C6 H5 N3

Synonyms/Common Names:

  • 1H-BENZOTRIAZOLE (9CI)

Known Uses:

PHOTOGRAPHIC RESTRAINER; CHEMICAL INTERMEDIATE; COPPER CORROSION INHIBITOR; INTERMEDIATE FOR DYES, PHARMACEUTICALS, IN DE-ICING FLUIDS FOR AIRCRAFT (HSDB 1990)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03521) Completed 
    • NTIS No. PB285202  (Peer Review 04/26/1978)
      Citation: Bioassay of 1H-Benzotriazole for Possible Carcinogenicity (CAS No. 95-14-7)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03521) Completed 
    • NTIS No. PB285202  (Peer Review 04/26/1978)
      Citation: Bioassay of 1H-Benzotriazole for Possible Carcinogenicity (CAS No. 95-14-7)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,300,30000 PPM/10 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03521) Report Complete 
    • TR-088 (NTIS No. PB285202)  (Peer Review 04/26/1978)
      Bioassay of 1H-Benzotriazole for Possible Carcinogenicity (CAS No. 95-14-7)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Equivocal 
      • Male Mice Negative 
      • Female Mice Equivocal 
    • Dose: R: 0,6700,12100 M:0,11700,23500 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (770824) Completed 
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Salmonella (NCI)  (N-9357) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella-NCI  Inconclusive 
  • Salmonella  (875607) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Weakly Positive 

Back to top

Web page last updated on November 24, 2008