National Toxicology Program

CASRN: 90-94-8

Formula: C17-H20-N2-O

Synonyms/Common Names:

• BIS (4-(DIMETHYLAMINO)PHENYL)-METHANONE (9CI)
• 4,4'-BIS(DIMETHYLAMINO)BENZOPHENONE

Known Uses:

DYE INTERMEDIATE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C02006) Completed 
  • NTIS No. PB299855  (Peer Review 10/25/1978)
    Citation: Bioassay of Michler's Ketone for Possible Carcinogenicity (CAS No. 90-94-8)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C02006) Completed 
  • NTIS No. PB299855  (Peer Review 10/25/1978)
    Citation: Bioassay of Michler's Ketone for Possible Carcinogenicity (CAS No. 90-94-8)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,680,14665, M: 0,440,13900 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C02006) Report Complete 
  • TR-181 (NTIS No. PB299855)  (Peer Review 10/25/1978)
    Bioassay of Michler's Ketone for Possible Carcinogenicity (CAS No. 90-94-8)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: MR: 0,250,500, FR: 0,500,1000, M: 0,1250,2500 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (242025) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Not Tested 
• In Vitro Cytogenetics (CA/SCE)  (913588) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma (NCI)  (G29620) Completed 
  • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
  • Mouse Lymphoma-NCI  Positive 
• Mouse Lymphoma (NCI)  (G71544) Completed 
  • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
  • Mouse Lymphoma-NCI  Positive 
• Salmonella (NCI)  (N-9252) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive 
• Salmonella  (635282) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Positive