National Toxicology Program

CASRN: 86-50-0

Formula: C10 H12 N3 O3 P S2

Synonyms/Common Names:

• 0,0-DIMETHYLPHOSPHORODITHIOIC ACID, S-((4-OXO-1,2,3-BENZOTRIAZIN-3(4H)-YL)METHYL)ESTER (9CI)

Known Uses:

AGRICULTURAL INSECTICIDE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00066) Completed 
  • NTIS No. PB286371  (Peer Review 06/29/1978)
    Citation: Bioassay of Azinphosmethyl for Possible Carcinogenicity (CAS No. 86-50-0)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00066) Completed 
  • NTIS No. PB286371  (Peer Review 06/29/1978)
    Citation: Bioassay of Azinphosmethyl for Possible Carcinogenicity (CAS No. 86-50-0)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R&FM: 0,62.5,1000, MM: 0,7.8,125 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00066) Report Complete 
  • TR-069 (NTIS No. PB286371)  (Peer Review 06/29/1978)
    Bioassay of Azinphosmethyl for Possible Carcinogenicity (CAS No. 86-50-0)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: FR&FM: 0,62.5,125, MR: 0,78,156 (AVG), MM: 0,31.3,62.5 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (930409) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Salmonella  (256211) Completed 
  •  Positive 
• Salmonella  (909450) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Weakly Positive