National Toxicology Program

CASRN: 77-65-6

Formula: C7-H13-BR-N2-O2

Synonyms/Common Names:

• N-(AMINOCARBONYL)-2-BROMO-2-ETHYL-BUTANAMIDE (9CI)
• BIOGASTRONE

Known Uses:

MILD CENTRAL NERVOUS SYSTEM DEPRESSANT, SEDATIVE, HYPNOTIC (MERCK 1989)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03805) Completed 
  • NTIS No. PB290130  (Peer Review 08/31/1978)
    Citation: Bioassay of Carbromal for Possible Carcinogenicity (CAS No. 77-65-6)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03805) Completed 
  • NTIS No. PB290130  (Peer Review 08/31/1978)
    Citation: Bioassay of Carbromal for Possible Carcinogenicity (CAS No. 77-65-6)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,1470,14700 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03805) Report Complete 
  • TR-173 (NTIS No. PB290130)  (Peer Review 08/31/1978)
    Bioassay of Carbromal for Possible Carcinogenicity (CAS No. 77-65-6)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,1250,2500 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (157167) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• In Vitro Cytogenetics (CA/SCE)  (480465) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Negative 
• Salmonella  (332501) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Salmonella  (652507) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative