National Toxicology Program

CASRN: 75-47-8

Formula: C-H-I3

Synonyms/Common Names:

• TRIIODOMETHANE (9CI)

Known Uses:

ANTISEPTIC AND ANTI-INFECTIVE PROPERTIES.

Short-Term Toxicity

• 14-Day (Gavage)  (C04568) Completed 
  • NTIS No. PB286344  (Peer Review 04/26/1978)
    Citation: Bioassay of Iodoform for Possible Carcinogenicity (CAS No. 75-47-8)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Gavage)  (C04568) Completed 
  • NTIS No. PB286344  (Peer Review 04/26/1978)
    Citation: Bioassay of Iodoform for Possible Carcinogenicity (CAS No. 75-47-8)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,56,562, M: 0,18,178 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C04568) Report Complete 
  • TR-110 (NTIS No. PB286344)  (Peer Review 04/26/1978)
    Bioassay of Iodoform for Possible Carcinogenicity (CAS No. 75-47-8)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: MR: 0,71,142 (AVG), FR: 0,27,55 (AVG), M: 0,47,93 (AVG) MG/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (123235) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Weakly Positive 
• Salmonella  (367919) Completed 
  •  Positive 
• Salmonella  (837276) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive